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Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression

Childs, C.E., Hoile, S.P., Burdge, G.C. and Calder, P.C. (2012) Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression Prostaglandins, Leukotrienes and Essential Fatty Acids, 86, (4-5), pp. 141-147. (doi:10.1016/j.plefa.2012.03.007). (PMID:22495065).

Record type: Article

Abstract

The mechanisms responsible for changes to long-chain polyunsaturated fatty acid (LC PUFA) status during pregnancy have not been fully elucidated. Tissue samples were collected from virgin and pregnant (day 12 and 20) female rats. LC PUFA status, sex hormone concentrations and hepatic mRNA expression of FADS1, FADS2 and elongase were assessed. Day 20 gestation females had higher plasma and liver docosahexaenoic acid and lower arachidonic acid content than virgin females (P<0.05). There was higher FADS2 mRNA expression during pregnancy (P=0.051). Progesterone and oestradiol concentrations positively correlated with hepatic FADS2 mRNA expression (P=0.043, P=0.004). Progesterone concentration positively correlated with hepatic n-6 docosapentaenoic acid content (P=0.006), and inversely correlated with intermediates in LC PUFA synthesis including n-3 docosapentaenoic acid, ?-linolenic acid and 20:2n-6 (P<0.05). Changes in progesterone and oestradiol during pregnancy may promote the synthesis of LC PUFA via increased FADS2 expression.

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e-pub ahead of print date: 9 April 2012
Keywords: pregnancy, fatty acid, sex hormones, desaturase
Organisations: Faculty of Medicine, Human Development & Health

Identifiers

Local EPrints ID: 337213
URI: http://eprints.soton.ac.uk/id/eprint/337213
PURE UUID: cf61a86e-846b-44ef-86fd-1e546fe6edcb
ORCID for C.E. Childs: ORCID iD orcid.org/0000-0001-6832-224X
ORCID for G.C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967

Catalogue record

Date deposited: 20 Apr 2012 09:31
Last modified: 18 Jul 2017 06:04

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Contributors

Author: C.E. Childs ORCID iD
Author: S.P. Hoile
Author: G.C. Burdge ORCID iD
Author: P.C. Calder

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