Macrocylic bisbibenzyl natural products and their chemical synthesis

Harrowven, David C. and Kostiuk, Sarah L. (2011) Macrocylic bisbibenzyl natural products and their chemical synthesis Natural Product Reports, 29, (2), pp. 223-242. (doi:10.1039/c1np00080b). (PMID:22089169).


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The macrocyclic bisbibenzyl family of natural products are commonly found in liverworts and other bryophytes, though the recent isolation of riccardin C from a primrose extract has demonstrated their existence in higher flowering plants. Each has a core comprising four aromatic rings and two ethano-bridges, being derived in Nature from two molecules of lunularin. Sub-classes are distinguished by the connectivity between these lunularin units, while individual natural products are distinguished by the hydroxy- and/or alkoxy-substituents decorating the core structures. Further diversification results
from halogenation and oxidation, which may lead to dimerization or the creation of additional rings.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1039/c1np00080b
ISSNs: 0265-0568 (print)
Keywords: natural products, halogenation, oxidation, dimerization, DNA
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH426 Genetics
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow
ePrint ID: 337216
Date :
Date Event
16 November 2011e-pub ahead of print
February 2012Published
Date Deposited: 20 Apr 2012 10:25
Last Modified: 17 Apr 2017 17:18
Further Information:Google Scholar

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