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Omega-3 polyunsaturated fatty acids and cardiovascular disease

Omega-3 polyunsaturated fatty acids and cardiovascular disease
Omega-3 polyunsaturated fatty acids and cardiovascular disease
The omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA; 22:6n-3) and eicosapentaenoic acid (EPA; 20:5n-3) (Figure 1) are naturally occurring fatty acids found in high amounts in seafood especially fatty fish (e.g. salmon, herring, sardines, mackerel, tuna). These fatty acids are also found in fish oil supplements. In the 1960s and 1970s it was observed that Greenland Inuits, native Alaskans and the inhabitants of Okinawa, Japan, had a much reduced risk of developing coronary artery disease compared to ‘western’ populations1-4 and that this was associated with a diet rich in n-3 PUFAs. Thus, the ‘cardioprotective’ hypothesis related to n-3 PUFA consumption was engendered. Much research has been carried out in the intervening years on the beneficial effects of consuming n-3 PUFAs. Here we review the data from epidemiological and interventional studies as well as mechanistic studies on the actions of dietary n-3 PUFAs in the cardiovascular system.
4-11
Yates, Clara M.
bf31d73c-79ec-43b9-8c6c-ee12023a8c09
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Rainger, G. Ed
f437d109-e403-40a4-895a-21f740503a86
Yates, Clara M.
bf31d73c-79ec-43b9-8c6c-ee12023a8c09
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Rainger, G. Ed
f437d109-e403-40a4-895a-21f740503a86

Yates, Clara M., Calder, Philip C. and Rainger, G. Ed (2011) Omega-3 polyunsaturated fatty acids and cardiovascular disease. Bulletin of the British Society for Cardiovascular Research, 24 (4), 4-11.

Record type: Review

Abstract

The omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA; 22:6n-3) and eicosapentaenoic acid (EPA; 20:5n-3) (Figure 1) are naturally occurring fatty acids found in high amounts in seafood especially fatty fish (e.g. salmon, herring, sardines, mackerel, tuna). These fatty acids are also found in fish oil supplements. In the 1960s and 1970s it was observed that Greenland Inuits, native Alaskans and the inhabitants of Okinawa, Japan, had a much reduced risk of developing coronary artery disease compared to ‘western’ populations1-4 and that this was associated with a diet rich in n-3 PUFAs. Thus, the ‘cardioprotective’ hypothesis related to n-3 PUFA consumption was engendered. Much research has been carried out in the intervening years on the beneficial effects of consuming n-3 PUFAs. Here we review the data from epidemiological and interventional studies as well as mechanistic studies on the actions of dietary n-3 PUFAs in the cardiovascular system.

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More information

Published date: October 2011
Organisations: Human Development & Health

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Local EPrints ID: 337271
URI: http://eprints.soton.ac.uk/id/eprint/337271
PURE UUID: 64dc6d1a-05df-4ab8-aafd-ae797957844d
ORCID for Philip C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

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Date deposited: 20 Apr 2012 14:13
Last modified: 31 May 2023 01:33

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Contributors

Author: Clara M. Yates
Author: G. Ed Rainger

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