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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper
Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper
Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.
0105-4538
842-853
Bousquet, J.
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Fokkens, W.
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Burney, P.
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Bachert, C.
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Akdis, C. A.
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Canonica, G. W.
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Dahlen, S.-E.
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Zuberbier, T.
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Bieber, T.
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Bonini, S.
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Howarth, P.
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Papadopoulos, N.
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Passalacqua, G.
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Schünemann, H. J.
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Simon, H.-U.
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Todo-Bom, A.
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Toskala, E.
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Zock, J. P.
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Bousquet, J.
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Fokkens, W.
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Burney, P.
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Durham, S. R.
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Bachert, C.
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Akdis, C. A.
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Canonica, G. W.
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Dahlen, S.-E.
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Zuberbier, T.
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Bieber, T.
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Bonini, S.
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Bousquet, P. J.
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Crameri, R.
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Gjomarkaj, M.
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Holland, C.
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Howarth, P.
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Humbert, M.
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Johnston, S. L.
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Kauffmann, F.
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Kowalski, M. L.
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Lambrecht, B.
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Lehmann, S.
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Leynaert, B.
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Lodrup-Carlsen, K.
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Mullol, J.
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Niggemann, B.
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Nizankowska-Mogilnicka, E.
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Papadopoulos, N.
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Passalacqua, G.
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Schünemann, H. J.
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Simon, H.-U.
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Todo-Bom, A.
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Toskala, E.
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Valenta, R.
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Wickman, M.
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Zock, J. P.
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Bousquet, J., Fokkens, W., Burney, P., Durham, S. R., Bachert, C., Akdis, C. A., Canonica, G. W., Dahlen, S.-E., Zuberbier, T., Bieber, T., Bonini, S., Bousquet, P. J., Brozek, J. L., Cardell, L.-O., Crameri, R., Custovic, A., Demoly, P., van Wijk, R. G., Gjomarkaj, M., Holland, C., Howarth, P., Humbert, M., Johnston, S. L., Kauffmann, F., Kowalski, M. L., Lambrecht, B., Lehmann, S., Leynaert, B., Lodrup-Carlsen, K., Mullol, J., Niggemann, B., Nizankowska-Mogilnicka, E., Papadopoulos, N., Passalacqua, G., Schünemann, H. J., Simon, H.-U., Todo-Bom, A., Toskala, E., Valenta, R., Wickman, M. and Zock, J. P. (2008) Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper. Allergy, 63 (7), 842-853. (doi:10.1111/j.1398-9995.2008.01715.x). (PMID:18588549)

Record type: Article

Abstract

Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.

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Published date: 28 June 2008
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 337424
URI: https://eprints.soton.ac.uk/id/eprint/337424
ISSN: 0105-4538
PURE UUID: 00163361-c05d-4dcc-99c0-7e601179ff3e

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Date deposited: 25 Apr 2012 12:03
Last modified: 16 Apr 2019 16:31

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Contributors

Author: J. Bousquet
Author: W. Fokkens
Author: P. Burney
Author: S. R. Durham
Author: C. Bachert
Author: C. A. Akdis
Author: G. W. Canonica
Author: S.-E. Dahlen
Author: T. Zuberbier
Author: T. Bieber
Author: S. Bonini
Author: P. J. Bousquet
Author: J. L. Brozek
Author: L.-O. Cardell
Author: R. Crameri
Author: A. Custovic
Author: P. Demoly
Author: R. G. van Wijk
Author: M. Gjomarkaj
Author: C. Holland
Author: P. Howarth
Author: M. Humbert
Author: S. L. Johnston
Author: F. Kauffmann
Author: M. L. Kowalski
Author: B. Lambrecht
Author: S. Lehmann
Author: B. Leynaert
Author: K. Lodrup-Carlsen
Author: J. Mullol
Author: B. Niggemann
Author: E. Nizankowska-Mogilnicka
Author: N. Papadopoulos
Author: G. Passalacqua
Author: H. J. Schünemann
Author: H.-U. Simon
Author: A. Todo-Bom
Author: E. Toskala
Author: R. Valenta
Author: M. Wickman
Author: J. P. Zock

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