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Associations between serum selenium and total plasma homocysteine during the acute phase of ischaemic stroke

Associations between serum selenium and total plasma homocysteine during the acute phase of ischaemic stroke
Associations between serum selenium and total plasma homocysteine during the acute phase of ischaemic stroke
Background/aims: risk of ischaemic stroke (IS) was associated with total homocysteine (tHCY). On the other hand, serum selenium (Se) exhibited anti-aging and cardiopreventive effects. Se and tHCY showed relationships in animals but these were contradictory or inconclusive in humans; therefore, we searched for such associations in acute IS.

Methods: ninety-four participants aged around 47 years were identified and 39 patients versus 46 healthy controls were analysed. Clinical, laboratory (blinded) and risk factor questionnaire methods were used. Comparison, correlation and multifactorial regression analyses were applied.

Results: IS patients were similar to controls concerning age and gender. IS was prevalent in the carotid system (76.9%); 82.1% had a subacute onset. IS patients expressed higher tHCY (14.65 ± 9.79 ?mol/l) and lower Se levels (1.3 ± 0.5 ?mol/l). Twice as many IS patients (23%) had optimal Se levels of <1.01 ?mol/l. Subjects with hyperhomocysteinaemia (tHCY ?15 ?mol/l) showed lower Se levels during IS; Se accounted for 15.4% of tHCY variations (R = –0.393; p = 0.015) with unit change increasing tHCY by 8.25 units. Se remained predictive of tHCY levels after adjustments (vitamin B6, fibrinogen, triglycerides).

Conclusions: lower Se was observed during acute IS, being inversely associated with and predicting increased tHCY levels. Of note, there were more IS patients with suboptimal Se than controls
0014-3022
298-303
Angelova, Evgeniya A.
47faf9a6-d1a6-47b5-a98d-50f4e73cea04
Atanassova, Penka A.
db224499-1eca-4548-8968-57f905c4582a
Chalakova, Nedka T.
efa94353-8340-4159-be40-ab213384eb62
Dimitrov, Borislav D.
366d715f-ffd9-45a1-8415-65de5488472f
Angelova, Evgeniya A.
47faf9a6-d1a6-47b5-a98d-50f4e73cea04
Atanassova, Penka A.
db224499-1eca-4548-8968-57f905c4582a
Chalakova, Nedka T.
efa94353-8340-4159-be40-ab213384eb62
Dimitrov, Borislav D.
366d715f-ffd9-45a1-8415-65de5488472f

Angelova, Evgeniya A., Atanassova, Penka A., Chalakova, Nedka T. and Dimitrov, Borislav D. (2008) Associations between serum selenium and total plasma homocysteine during the acute phase of ischaemic stroke. European Neurology, 60 (6), 298-303. (doi:10.1159/000157884). (PMID:18824858)

Record type: Article

Abstract

Background/aims: risk of ischaemic stroke (IS) was associated with total homocysteine (tHCY). On the other hand, serum selenium (Se) exhibited anti-aging and cardiopreventive effects. Se and tHCY showed relationships in animals but these were contradictory or inconclusive in humans; therefore, we searched for such associations in acute IS.

Methods: ninety-four participants aged around 47 years were identified and 39 patients versus 46 healthy controls were analysed. Clinical, laboratory (blinded) and risk factor questionnaire methods were used. Comparison, correlation and multifactorial regression analyses were applied.

Results: IS patients were similar to controls concerning age and gender. IS was prevalent in the carotid system (76.9%); 82.1% had a subacute onset. IS patients expressed higher tHCY (14.65 ± 9.79 ?mol/l) and lower Se levels (1.3 ± 0.5 ?mol/l). Twice as many IS patients (23%) had optimal Se levels of <1.01 ?mol/l. Subjects with hyperhomocysteinaemia (tHCY ?15 ?mol/l) showed lower Se levels during IS; Se accounted for 15.4% of tHCY variations (R = –0.393; p = 0.015) with unit change increasing tHCY by 8.25 units. Se remained predictive of tHCY levels after adjustments (vitamin B6, fibrinogen, triglycerides).

Conclusions: lower Se was observed during acute IS, being inversely associated with and predicting increased tHCY levels. Of note, there were more IS patients with suboptimal Se than controls

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More information

e-pub ahead of print date: 27 September 2008
Published date: October 2008
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 337457
URI: https://eprints.soton.ac.uk/id/eprint/337457
ISSN: 0014-3022
PURE UUID: 693c36ef-aa13-4af5-a2cb-42d7c6c26987

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Date deposited: 26 Apr 2012 10:58
Last modified: 16 Jul 2019 22:06

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