NK cell receptors: evolution and diversity
NK cell receptors: evolution and diversity
Natural Killer cell functions are regulated by combinations of activating and inhibitory receptors, derived from a number of different gene families. This review focuses on receptors for MHC class I, which include the killer cell immunoglobulin-like receptors (KIR) and the CD94:NKG2 family of receptors. In particular the KIR are diverse and rapidly co-evolving with their classical MHC class I ligands. Thus NK cells are part of the innate immune system that are continuing to adapt to the challenges of pathogens.
787-796
Borhis, Gwenoline
8a33db74-836f-4e0b-a42f-b0402f44fa8a
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
September 2011
Borhis, Gwenoline
8a33db74-836f-4e0b-a42f-b0402f44fa8a
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Borhis, Gwenoline and Khakoo, Salim I.
(2011)
NK cell receptors: evolution and diversity.
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15 (9), .
(doi:10.4267/2042/46021).
Abstract
Natural Killer cell functions are regulated by combinations of activating and inhibitory receptors, derived from a number of different gene families. This review focuses on receptors for MHC class I, which include the killer cell immunoglobulin-like receptors (KIR) and the CD94:NKG2 family of receptors. In particular the KIR are diverse and rapidly co-evolving with their classical MHC class I ligands. Thus NK cells are part of the innate immune system that are continuing to adapt to the challenges of pathogens.
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e-pub ahead of print date: February 2011
Published date: September 2011
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 337524
URI: http://eprints.soton.ac.uk/id/eprint/337524
PURE UUID: d2c6ca15-bede-4b73-ad6c-64fcb0396a2b
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Date deposited: 26 Apr 2012 14:00
Last modified: 15 Mar 2024 03:12
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Author:
Gwenoline Borhis
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