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Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans

Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
That NK cell receptors engage fast-evolving MHC class I ligands suggests that they, too, evolve rapidly. To test this hypothesis, the structure and class I specificity of chimpanzee KIR and CD94:NKG2 receptors were determined and compared to their human counterparts. The KIR families are divergent, with only three KIR conserved between chimpanzees and humans. By contrast, CD94:NKG2 receptors are conserved. Whereas receptors for polymorphic class I are divergent, those for nonpolymorphic class I are conserved. Although chimpanzee and human NK cells exhibit identical receptor specificities for MHC-C, they are mediated by nonorthologous KIR. These results demonstrate the rapid evolution of NK cell receptor systems and imply that “catching up” with class I is not the only force driving this evolution.
1097-4180
687-698
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Rajalingam, Raja
cfaf4da4-5bac-42ab-a235-8fc700b65987
Shum, Benny P.
b487c075-3263-4489-a5dc-8aa92fab4970
Weidenbach, Kristin
d8b3ba71-f588-4c8b-a0d6-d90a8ae3df44
Flodin, Laura
ccd577eb-5639-40ff-bcb7-d31e58bb3a5f
Muir, David G.
64257a0c-1c56-4cf7-b184-90bc03f50768
Canavez, Flavio
128a4f18-ab4e-4ea1-80a5-6299980437c2
Cooper, Stewart L.
f645b03e-0a3f-4751-af60-5b5327a7753d
Valiante, Nicholas M.
d95e0310-08d5-4ac4-99cd-ba0287d7a24a
Lanier, Lewis L.
3fc96f6c-1523-46e7-b8ba-1f97af8ea281
Parnham, Peter
2416fd40-7ff8-48cd-a985-fdd089cae863
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Rajalingam, Raja
cfaf4da4-5bac-42ab-a235-8fc700b65987
Shum, Benny P.
b487c075-3263-4489-a5dc-8aa92fab4970
Weidenbach, Kristin
d8b3ba71-f588-4c8b-a0d6-d90a8ae3df44
Flodin, Laura
ccd577eb-5639-40ff-bcb7-d31e58bb3a5f
Muir, David G.
64257a0c-1c56-4cf7-b184-90bc03f50768
Canavez, Flavio
128a4f18-ab4e-4ea1-80a5-6299980437c2
Cooper, Stewart L.
f645b03e-0a3f-4751-af60-5b5327a7753d
Valiante, Nicholas M.
d95e0310-08d5-4ac4-99cd-ba0287d7a24a
Lanier, Lewis L.
3fc96f6c-1523-46e7-b8ba-1f97af8ea281
Parnham, Peter
2416fd40-7ff8-48cd-a985-fdd089cae863

Khakoo, Salim I., Rajalingam, Raja, Shum, Benny P., Weidenbach, Kristin, Flodin, Laura, Muir, David G., Canavez, Flavio, Cooper, Stewart L., Valiante, Nicholas M., Lanier, Lewis L. and Parnham, Peter (2000) Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans. Immunity, 12 (6), 687-698. (doi:10.1016/S1074-7613(00)80219-8). (PMID:10894168)

Record type: Article

Abstract

That NK cell receptors engage fast-evolving MHC class I ligands suggests that they, too, evolve rapidly. To test this hypothesis, the structure and class I specificity of chimpanzee KIR and CD94:NKG2 receptors were determined and compared to their human counterparts. The KIR families are divergent, with only three KIR conserved between chimpanzees and humans. By contrast, CD94:NKG2 receptors are conserved. Whereas receptors for polymorphic class I are divergent, those for nonpolymorphic class I are conserved. Although chimpanzee and human NK cells exhibit identical receptor specificities for MHC-C, they are mediated by nonorthologous KIR. These results demonstrate the rapid evolution of NK cell receptor systems and imply that “catching up” with class I is not the only force driving this evolution.

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Published date: 1 June 2000
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 337528
URI: https://eprints.soton.ac.uk/id/eprint/337528
ISSN: 1097-4180
PURE UUID: 27b9e553-c401-4749-a09f-70c6c8cdeb88

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Date deposited: 27 Apr 2012 12:26
Last modified: 16 Jul 2019 22:06

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Contributors

Author: Salim I. Khakoo
Author: Raja Rajalingam
Author: Benny P. Shum
Author: Kristin Weidenbach
Author: Laura Flodin
Author: David G. Muir
Author: Flavio Canavez
Author: Stewart L. Cooper
Author: Nicholas M. Valiante
Author: Lewis L. Lanier
Author: Peter Parnham

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