The University of Southampton
University of Southampton Institutional Repository

Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity

Khakoo, Salim I., Soni, P.N., Savage, K., Brown, D., Dhillon, A.P., Poulter, L.W. and Dusheiko, G.M. (1997) Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity The American Journal of Pathology, 150, (3), pp. 963-970. (PMID:9060834).

Record type: Article


The pathogenesis of chronic hepatitis C and the mechanisms underlying progressive liver disease in patients with chronic hepatitis C infection are poorly understood. To demonstrate which inflammatory cells might be responsible for the necroinflammatory damage in chronic hepatitis C infection, we have correlated the phenotype of the intrahepatic lymphocytes and macrophages with histological activity in liver biopsy and explant specimens from 19 patients with chronic hepatitis C infection. In all stages of disease, more CD8+ than CD4+ lymphocytes were found. However, histologically active versus histologically mild hepatitis was associated with a trend toward greater parenchymal concentrations of CD4+ lymphocytes (0.71 +/- 0.27 per 10(4) microns 2 versus 0.35 +/- 0.15; not significant), significantly less parenchymal CD8+ lymphocytes (0.90 +/- 0.1 versus 1.70 +/- 0.3; t = 2.32, P = 0.03) and a greater parenchymal CD4/CD8 ratio (4.1 +/- 2.8 versus 0.91 +/- 0.3; t = 1.65, P = 0.07). No difference was found in the number of cells containing cytotoxic granules between the two groups. Greater numbers of CD4+ lymphocytes were found in liver biopsy specimens with little or no staining for hepatitis C virus antigen (1.47 +/- 0.88 versus 0.27 +/- 0.27; t = 2.28, P < 0.05). No significant differences were found in the macrophage subsets between the three stages of disease. Our data suggest that active histological disease in chronic hepatitis C infection may be associated with an increase in CD4+ lymphocytes and suggest that CD4+ T cells may play an important role in the hepatic injury in these patients.

Full text not available from this repository.

More information

Published date: March 1997
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 337564
ISSN: 0002-9440
PURE UUID: 2bf9f8d2-541e-4d09-9c7e-fe1936ff8810

Catalogue record

Date deposited: 30 Apr 2012 10:50
Last modified: 18 Jul 2017 06:02

Export record


Author: Salim I. Khakoo
Author: P.N. Soni
Author: K. Savage
Author: D. Brown
Author: A.P. Dhillon
Author: L.W. Poulter
Author: G.M. Dusheiko

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.