Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity
Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity
The pathogenesis of chronic hepatitis C and the mechanisms underlying progressive liver disease in patients with chronic hepatitis C infection are poorly understood. To demonstrate which inflammatory cells might be responsible for the necroinflammatory damage in chronic hepatitis C infection, we have correlated the phenotype of the intrahepatic lymphocytes and macrophages with histological activity in liver biopsy and explant specimens from 19 patients with chronic hepatitis C infection. In all stages of disease, more CD8+ than CD4+ lymphocytes were found. However, histologically active versus histologically mild hepatitis was associated with a trend toward greater parenchymal concentrations of CD4+ lymphocytes (0.71 +/- 0.27 per 10(4) microns 2 versus 0.35 +/- 0.15; not significant), significantly less parenchymal CD8+ lymphocytes (0.90 +/- 0.1 versus 1.70 +/- 0.3; t = 2.32, P = 0.03) and a greater parenchymal CD4/CD8 ratio (4.1 +/- 2.8 versus 0.91 +/- 0.3; t = 1.65, P = 0.07). No difference was found in the number of cells containing cytotoxic granules between the two groups. Greater numbers of CD4+ lymphocytes were found in liver biopsy specimens with little or no staining for hepatitis C virus antigen (1.47 +/- 0.88 versus 0.27 +/- 0.27; t = 2.28, P < 0.05). No significant differences were found in the macrophage subsets between the three stages of disease. Our data suggest that active histological disease in chronic hepatitis C infection may be associated with an increase in CD4+ lymphocytes and suggest that CD4+ T cells may play an important role in the hepatic injury in these patients.
963-970
Khakoo, Salim I.
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Soni, P.N.
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Savage, K.
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Brown, D.
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Dhillon, A.P.
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Poulter, L.W.
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Dusheiko, G.M.
d38496da-e082-430c-b719-4230a4addc6c
March 1997
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Soni, P.N.
1329e3a3-66b8-40a6-9230-8eb93eaec1e4
Savage, K.
730b3ee4-170f-4ad5-bcbf-40e6ce2697db
Brown, D.
066e8669-5678-4f7c-96eb-e8e29a9a4cfb
Dhillon, A.P.
865403bc-088e-4e92-9e84-cf31ec418ac6
Poulter, L.W.
5254c571-5ac5-49d5-97ab-5b0dede4e054
Dusheiko, G.M.
d38496da-e082-430c-b719-4230a4addc6c
Khakoo, Salim I., Soni, P.N., Savage, K., Brown, D., Dhillon, A.P., Poulter, L.W. and Dusheiko, G.M.
(1997)
Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity.
The American Journal of Pathology, 150 (3), .
(PMID:9060834)
Abstract
The pathogenesis of chronic hepatitis C and the mechanisms underlying progressive liver disease in patients with chronic hepatitis C infection are poorly understood. To demonstrate which inflammatory cells might be responsible for the necroinflammatory damage in chronic hepatitis C infection, we have correlated the phenotype of the intrahepatic lymphocytes and macrophages with histological activity in liver biopsy and explant specimens from 19 patients with chronic hepatitis C infection. In all stages of disease, more CD8+ than CD4+ lymphocytes were found. However, histologically active versus histologically mild hepatitis was associated with a trend toward greater parenchymal concentrations of CD4+ lymphocytes (0.71 +/- 0.27 per 10(4) microns 2 versus 0.35 +/- 0.15; not significant), significantly less parenchymal CD8+ lymphocytes (0.90 +/- 0.1 versus 1.70 +/- 0.3; t = 2.32, P = 0.03) and a greater parenchymal CD4/CD8 ratio (4.1 +/- 2.8 versus 0.91 +/- 0.3; t = 1.65, P = 0.07). No difference was found in the number of cells containing cytotoxic granules between the two groups. Greater numbers of CD4+ lymphocytes were found in liver biopsy specimens with little or no staining for hepatitis C virus antigen (1.47 +/- 0.88 versus 0.27 +/- 0.27; t = 2.28, P < 0.05). No significant differences were found in the macrophage subsets between the three stages of disease. Our data suggest that active histological disease in chronic hepatitis C infection may be associated with an increase in CD4+ lymphocytes and suggest that CD4+ T cells may play an important role in the hepatic injury in these patients.
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Published date: March 1997
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 337564
URI: http://eprints.soton.ac.uk/id/eprint/337564
ISSN: 0002-9440
PURE UUID: 2bf9f8d2-541e-4d09-9c7e-fe1936ff8810
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Date deposited: 30 Apr 2012 10:50
Last modified: 10 May 2023 01:37
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Author:
P.N. Soni
Author:
K. Savage
Author:
D. Brown
Author:
A.P. Dhillon
Author:
L.W. Poulter
Author:
G.M. Dusheiko
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