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Too much of a good thing: management of BCG vaccine overdose

Record type: Article

A 14-year-old girl was inadvertently immunised with an excessively large dose of BCG-Connaught vaccine (1.0 ml instead of 0.1 ml). Examination of the patient a few hours later revealed a subcutaneous fluctuant tender lump at the injection site. This was surgically excised within 12h of immunisation and she was treated with isoniazid and rifampicin for six weeks. The patient developed no complications, other than a minor surgical scar. This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose.

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Citation

Ritz, Nicole, Tebruegge, Marc, Streeton, Jonathan and Curtis, Nigel (2009) Too much of a good thing: management of BCG vaccine overdose Vaccine, 27, (41), pp. 5562-5564. (doi:10.1016/j.vaccine.2009.07.043). (PMID:19654063).

More information

Published date: 18 September 2009
Keywords: bcg, overdose, vaccine, immunisation, tuberculosis, medical error
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 337638
URI: http://eprints.soton.ac.uk/id/eprint/337638
PURE UUID: 873c4bde-a0e8-4862-bd42-4722250d138f

Catalogue record

Date deposited: 02 May 2012 08:39
Last modified: 18 Jul 2017 06:02

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Contributors

Author: Nicole Ritz
Author: Marc Tebruegge
Author: Jonathan Streeton
Author: Nigel Curtis

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