The University of Southampton
University of Southampton Institutional Repository

Too much of a good thing: management of BCG vaccine overdose

Ritz, Nicole, Tebruegge, Marc, Streeton, Jonathan and Curtis, Nigel (2009) Too much of a good thing: management of BCG vaccine overdose Vaccine, 27, (41), pp. 5562-5564. (doi:10.1016/j.vaccine.2009.07.043). (PMID:19654063).

Record type: Article


A 14-year-old girl was inadvertently immunised with an excessively large dose of BCG-Connaught vaccine (1.0 ml instead of 0.1 ml). Examination of the patient a few hours later revealed a subcutaneous fluctuant tender lump at the injection site. This was surgically excised within 12h of immunisation and she was treated with isoniazid and rifampicin for six weeks. The patient developed no complications, other than a minor surgical scar. This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose.

Full text not available from this repository.

More information

Published date: 18 September 2009
Keywords: bcg, overdose, vaccine, immunisation, tuberculosis, medical error
Organisations: Faculty of Medicine


Local EPrints ID: 337638
PURE UUID: 873c4bde-a0e8-4862-bd42-4722250d138f

Catalogue record

Date deposited: 02 May 2012 08:39
Last modified: 18 Jul 2017 06:02

Export record



Author: Nicole Ritz
Author: Marc Tebruegge
Author: Jonathan Streeton
Author: Nigel Curtis

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.