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A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial

Boyd, K.D., Ross, F.M., Chiecchio, L., Dagrada, G.P., Konn, Z.J., Tapper, W.J., Walker, B.A., Wardell, C.P., Gregory, W.M., Szubert, A.J., Bell, S.E., Child, J.A., Jackson, G.H., Davies, F.E. and Morgan, G.J. (2012) A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial Leukemia, 26, (2), pp. 349-355. (doi:10.1038/leu.2011.204). (PMID:21836613).

Record type: Article


The association of genetic lesions detected by fluorescence in situ hybridization (FISH) with survival was analyzed in 1069 patients with newly presenting myeloma treated in the Medical Research Council Myeloma IX trial, with the aim of identifying patients associated with the worst prognosis. A comprehensive FISH panel was performed, and the lesions associated with short progression-free survival and overall survival (OS) in multivariate analysis were +1q21, del(17p13) and an adverse immunoglobulin heavy chain gene (IGH) translocation group incorporating t(4;14), t(14;16) and t(14;20). These lesions frequently co-segregated, and there was an association between the accumulation of these adverse FISH lesions and a progressive impairment of survival. This observation was used to define a series of risk groups based on number of adverse lesions. Taking this approach, we defined a favorable risk group by the absence of adverse genetic lesions, an intermediate group with one adverse lesion and a high-risk group defined by the co-segregation of >1 adverse lesion. This genetic grouping was independent of the International Staging System (ISS) and so was integrated with the ISS to identify an ultra-high-risk group defined by ISS II or III and >1 adverse lesion. This group constituted 13.8% of patients and was associated with a median OS of 19.4 months.

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Published date: February 2012
Organisations: Human Development & Health


Local EPrints ID: 337683
ISSN: 0887-6924
PURE UUID: c76909e8-3007-4a6a-ad94-0fa1344e20fb

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Date deposited: 02 May 2012 11:27
Last modified: 18 Jul 2017 06:01

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Author: K.D. Boyd
Author: F.M. Ross
Author: L. Chiecchio
Author: G.P. Dagrada
Author: Z.J. Konn
Author: W.J. Tapper
Author: B.A. Walker
Author: C.P. Wardell
Author: W.M. Gregory
Author: A.J. Szubert
Author: S.E. Bell
Author: J.A. Child
Author: G.H. Jackson
Author: F.E. Davies
Author: G.J. Morgan

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