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Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: a comparative approach

Fago, Angela, Jensen, Frank B., Tota, Bruno, Feelisch, Martin, Olson, Kenneth R., Helbo, Signe, Lefevre, Sjannie, Mancardi, Daniele, Palumbo, Anna, Sandvik, Guro K. and Skovgaard, Nini (2012) Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: a comparative approach Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology, 162, (1), pp. 1-6. (doi:10.1016/j.cbpa.2012.01.011). (PMID:22314020).

Record type: Article


Hydrogen sulfide (H(2)S), nitric oxide (NO) and nitrite (NO(2)(-)) are formed in vivo and are of crucial importance in the tissue response to hypoxia, particularly in the cardiovascular system, where these signaling molecules are involved in a multitude of processes including the regulation of vascular tone, cellular metabolic function and cytoprotection. This report summarizes current advances on the mechanisms by which these signaling pathways act and may have evolved in animals with different tolerance to hypoxia, as presented and discussed during the scientific sessions of the annual meeting of the Society for Experimental Biology in 2011 in Glasgow. It also highlights the need and potential for a comparative approach of study and collaborative effort to identify potential link(s) between the signaling pathways involving NO, nitrite and H(2)S in the whole-body responses to hypoxia.

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e-pub ahead of print date: 31 January 2012
Published date: May 2012
Keywords: gasotransmitter, oxygen sensing, s-nitrosothiols, vasoconstriction, vasodilation, cytoprotection
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 337691
ISSN: 1095-6433
PURE UUID: cd78de8e-ec76-43b0-9be4-a299fcb657e6
ORCID for Martin Feelisch: ORCID iD

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Date deposited: 02 May 2012 11:22
Last modified: 18 Jul 2017 06:01

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Author: Angela Fago
Author: Frank B. Jensen
Author: Bruno Tota
Author: Martin Feelisch ORCID iD
Author: Kenneth R. Olson
Author: Signe Helbo
Author: Sjannie Lefevre
Author: Daniele Mancardi
Author: Anna Palumbo
Author: Guro K. Sandvik
Author: Nini Skovgaard

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