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Gender disparities in the tumor genetics and clinical outcome of multiple myeloma

Gender disparities in the tumor genetics and clinical outcome of multiple myeloma
Gender disparities in the tumor genetics and clinical outcome of multiple myeloma
Background: Several cancer types have differences in incidence and clinical outcome dependent on gender, but these are not well described in myeloma. The aim of this study was to characterize gender disparities in myeloma.

Methods: We investigated the association of gender with the prevalence of tumor genetic lesions and the clinical outcome of 1,960 patients enrolled in the phase III clinical trial MRC Myeloma IX. Genetic lesions were characterized by FISH.

Results: Disparities were found in the prevalence of primary genetic lesions with immunoglobulin heavy chain gene (IGH) translocations being more common in women (50% of female patients vs. 38% of male patients, P < 0.001) and hyperdiploidy being more common in men (50% female vs. 62% male, P < 0.001). There were also differences in secondary genetic events with del(13q) (52% female vs. 41% male, P < 0.001) and +1q (43% female vs. 36% male, P = 0.042) being found more frequently in female myeloma patients. Female gender was associated with inferior overall survival (median: 44.8 months female vs. 49.9 months male, P = 0.020).

Conclusions: We found gender-dependent differences in the prevalence of the primary genetic events of myeloma, with IGH translocations being more common in women and hyperdiploidy more common in men. This genetic background may impact subsequent genetic events such as +1q and del(13q), which were both more frequent in women. The higher prevalence of lesions associated with poor prognosis in the female myeloma population, such as t(4;14), t(14;16) and +1q, may adversely affect clinical outcome.
1055-9965
1703-1707
Boyd, Kevin D.
20bdd6c8-3f06-4cab-9e12-99903ec18129
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba
Chiecchio, Laura
3d2f63e3-3df1-4655-8478-00ecd89d009c
Dagrada, GianPaolo
a149df7d-0de2-487d-8697-0a8913b998cd
Konn, Zoe J.
525b4648-7c88-488a-aefa-0018ac485eb4
Tapper, William J.
9d5ddc92-a8dd-4c78-ac67-c5867b62724c
Walker, Brian A.
7e45e107-ca85-4368-8673-7177f2328405
Wardell, Christopher P.
0d498cee-324b-457c-adff-7193c16cf2d5
Gregory, Walter M.
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Szubert, Alex J.
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Davies, Faith E.
9ea9e143-ac51-431b-8cb5-57b8dc0a38af
Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939
Boyd, Kevin D.
20bdd6c8-3f06-4cab-9e12-99903ec18129
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba
Chiecchio, Laura
3d2f63e3-3df1-4655-8478-00ecd89d009c
Dagrada, GianPaolo
a149df7d-0de2-487d-8697-0a8913b998cd
Konn, Zoe J.
525b4648-7c88-488a-aefa-0018ac485eb4
Tapper, William J.
9d5ddc92-a8dd-4c78-ac67-c5867b62724c
Walker, Brian A.
7e45e107-ca85-4368-8673-7177f2328405
Wardell, Christopher P.
0d498cee-324b-457c-adff-7193c16cf2d5
Gregory, Walter M.
4a7a4c5a-0a88-4ba2-8f08-0c035dd0b6db
Szubert, Alex J.
01b61a54-6aa5-4576-a6c6-1b58e933118d
Davies, Faith E.
9ea9e143-ac51-431b-8cb5-57b8dc0a38af
Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939

Boyd, Kevin D., Ross, Fiona M., Chiecchio, Laura, Dagrada, GianPaolo, Konn, Zoe J., Tapper, William J., Walker, Brian A., Wardell, Christopher P., Gregory, Walter M., Szubert, Alex J., Davies, Faith E. and Morgan, Gareth J. (2011) Gender disparities in the tumor genetics and clinical outcome of multiple myeloma. Cancer Epidemiology, Biomarkers & Prevention, 20 (8), 1703-1707. (doi:10.1158/1055-9965.EPI-11-0157). (PMID:21680536)

Record type: Article

Abstract

Background: Several cancer types have differences in incidence and clinical outcome dependent on gender, but these are not well described in myeloma. The aim of this study was to characterize gender disparities in myeloma.

Methods: We investigated the association of gender with the prevalence of tumor genetic lesions and the clinical outcome of 1,960 patients enrolled in the phase III clinical trial MRC Myeloma IX. Genetic lesions were characterized by FISH.

Results: Disparities were found in the prevalence of primary genetic lesions with immunoglobulin heavy chain gene (IGH) translocations being more common in women (50% of female patients vs. 38% of male patients, P < 0.001) and hyperdiploidy being more common in men (50% female vs. 62% male, P < 0.001). There were also differences in secondary genetic events with del(13q) (52% female vs. 41% male, P < 0.001) and +1q (43% female vs. 36% male, P = 0.042) being found more frequently in female myeloma patients. Female gender was associated with inferior overall survival (median: 44.8 months female vs. 49.9 months male, P = 0.020).

Conclusions: We found gender-dependent differences in the prevalence of the primary genetic events of myeloma, with IGH translocations being more common in women and hyperdiploidy more common in men. This genetic background may impact subsequent genetic events such as +1q and del(13q), which were both more frequent in women. The higher prevalence of lesions associated with poor prognosis in the female myeloma population, such as t(4;14), t(14;16) and +1q, may adversely affect clinical outcome.

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More information

e-pub ahead of print date: 15 June 2011
Published date: August 2011
Organisations: Human Development & Health

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Local EPrints ID: 337722
URI: https://eprints.soton.ac.uk/id/eprint/337722
ISSN: 1055-9965
PURE UUID: 31617b7c-0c2f-48dd-9c49-29c13a976634

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Date deposited: 02 May 2012 11:54
Last modified: 11 Sep 2017 16:33

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Contributors

Author: Kevin D. Boyd
Author: Fiona M. Ross
Author: Laura Chiecchio
Author: GianPaolo Dagrada
Author: Zoe J. Konn
Author: Brian A. Walker
Author: Christopher P. Wardell
Author: Walter M. Gregory
Author: Alex J. Szubert
Author: Faith E. Davies
Author: Gareth J. Morgan

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