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Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma

Johnson, David C., Corthals, Sophie L., Walker, Brian A., Ross, Fiona M., Gregory, Walter M., Dickens, Nicholas J., Lokhorst, Henk M., Goldschmidt, Hartmut, Davies, Faith E., Durie, Brian G. M., Van Ness, Brian, Child, J. Anthony, Sonneveld, Pieter and Morgan, Gareth J. (2011) Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma Journal of Clinical Oncology, 29, (7), pp. 797-804. (doi:10.1200/JCO.2010.28.0792). (PMID:21245424).

Record type: Article

Abstract

Our results are consistent with the hypothesis that an individual's risk of developing a peripheral neuropathy after thalidomide treatment can be mediated by polymorphisms in genes governing repair mechanisms and inflammation in the peripheral nervous system. These findings will contribute to the development of future neuroprotective strategies with thalidomide therapy and the better use of this important compound.

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e-pub ahead of print date: 18 January 2011
Published date: 1 March 2011
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 337735
URI: http://eprints.soton.ac.uk/id/eprint/337735
ISSN: 1527-7755
PURE UUID: a2abcbce-8271-4131-a4d2-8ac25c6b1c0a

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Date deposited: 02 May 2012 14:03
Last modified: 18 Jul 2017 06:01

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Contributors

Author: David C. Johnson
Author: Sophie L. Corthals
Author: Brian A. Walker
Author: Fiona M. Ross
Author: Walter M. Gregory
Author: Nicholas J. Dickens
Author: Henk M. Lokhorst
Author: Hartmut Goldschmidt
Author: Faith E. Davies
Author: Brian G. M. Durie
Author: Brian Van Ness
Author: J. Anthony Child
Author: Pieter Sonneveld
Author: Gareth J. Morgan

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