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Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma

Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma
Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma
Our results are consistent with the hypothesis that an individual's risk of developing a peripheral neuropathy after thalidomide treatment can be mediated by polymorphisms in genes governing repair mechanisms and inflammation in the peripheral nervous system. These findings will contribute to the development of future neuroprotective strategies with thalidomide therapy and the better use of this important compound.
1527-7755
797-804
Johnson, David C.
95bd8f42-2b59-4788-86dd-a32087bf554b
Corthals, Sophie L.
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Walker, Brian A.
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Ross, Fiona M.
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Gregory, Walter M.
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Dickens, Nicholas J.
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Lokhorst, Henk M.
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Goldschmidt, Hartmut
f0cecca6-05ba-4462-8fa5-5bb85d0db5ad
Davies, Faith E.
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Durie, Brian G. M.
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Van Ness, Brian
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Child, J. Anthony
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Sonneveld, Pieter
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Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939
Johnson, David C.
95bd8f42-2b59-4788-86dd-a32087bf554b
Corthals, Sophie L.
f09a87aa-076d-4b12-a1d3-e9161b7f4de5
Walker, Brian A.
7e45e107-ca85-4368-8673-7177f2328405
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba
Gregory, Walter M.
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Dickens, Nicholas J.
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Lokhorst, Henk M.
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Goldschmidt, Hartmut
f0cecca6-05ba-4462-8fa5-5bb85d0db5ad
Davies, Faith E.
9ea9e143-ac51-431b-8cb5-57b8dc0a38af
Durie, Brian G. M.
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Van Ness, Brian
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Child, J. Anthony
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Sonneveld, Pieter
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Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939

Johnson, David C., Corthals, Sophie L., Walker, Brian A., Ross, Fiona M., Gregory, Walter M., Dickens, Nicholas J., Lokhorst, Henk M., Goldschmidt, Hartmut, Davies, Faith E., Durie, Brian G. M., Van Ness, Brian, Child, J. Anthony, Sonneveld, Pieter and Morgan, Gareth J. (2011) Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma. Journal of Clinical Oncology, 29 (7), 797-804. (doi:10.1200/JCO.2010.28.0792). (PMID:21245424)

Record type: Article

Abstract

Our results are consistent with the hypothesis that an individual's risk of developing a peripheral neuropathy after thalidomide treatment can be mediated by polymorphisms in genes governing repair mechanisms and inflammation in the peripheral nervous system. These findings will contribute to the development of future neuroprotective strategies with thalidomide therapy and the better use of this important compound.

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More information

e-pub ahead of print date: 18 January 2011
Published date: 1 March 2011
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 337735
URI: http://eprints.soton.ac.uk/id/eprint/337735
ISSN: 1527-7755
PURE UUID: a2abcbce-8271-4131-a4d2-8ac25c6b1c0a

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Date deposited: 02 May 2012 14:03
Last modified: 14 Mar 2024 10:57

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Contributors

Author: David C. Johnson
Author: Sophie L. Corthals
Author: Brian A. Walker
Author: Fiona M. Ross
Author: Walter M. Gregory
Author: Nicholas J. Dickens
Author: Henk M. Lokhorst
Author: Hartmut Goldschmidt
Author: Faith E. Davies
Author: Brian G. M. Durie
Author: Brian Van Ness
Author: J. Anthony Child
Author: Pieter Sonneveld
Author: Gareth J. Morgan

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