Interaction of fullerenes C60 with large unilamellar vesicles
Interaction of fullerenes C60 with large unilamellar vesicles
In order to explore the fullerene-lipid interaction, we have studied\nthe effects caused by C-60 on Large Unilamellar Vesicles (LUV). For\nthis purpose liposomes composed of L-a Phosphatidylcholine (PC) and\n1,2-dimyristoyl-sn-glycero-3-phospocholine (DMPC) and Cholesterol\n(Chol) in 2:1 molar ratio were used. The dispersions were characterized\nby means of Dynamic Light Scattering (DLS), zeta-potential measurements\nand Differential Scanning Calorimetry studies (DSC). The incorporation\nof C-60 into liposomes altered their physicochemical properties. A\nreduction to the mean diameter of the liposomes was observed when C-60\nwere incorporated, which might imply deformations on the lipid membrane\ninduced by fullerenes. An increase to the surface charge of the\nliposomes was noticed when C-60 molecules were present in the membrane\nproviding evidence of their successful incorporation into the liposomal\nbilayers. Finally the miscibility of liposomes with C-60 was\ninvestigated by DSC. Alterations occurred to the main transition of the\nliposomes when C-60 molecules were present in the membrane might be\nattributed to the penetration of the carbonaceous material into the\nlipid bilayers.
416-420
Katsamenis, Orestis L.
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Bouropoulos, Nikolaos
fadadea1-2aa2-4cd9-a7e5-33ba790cd45f
Fatouros, Dimitrios G.
4a716c96-a8ba-4fbf-b3db-3b2a3a2794c4
1 August 2009
Katsamenis, Orestis L.
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Bouropoulos, Nikolaos
fadadea1-2aa2-4cd9-a7e5-33ba790cd45f
Fatouros, Dimitrios G.
4a716c96-a8ba-4fbf-b3db-3b2a3a2794c4
Katsamenis, Orestis L., Bouropoulos, Nikolaos and Fatouros, Dimitrios G.
(2009)
Interaction of fullerenes C60 with large unilamellar vesicles.
Journal of Biomedical Nanotechnology, 5 (4), .
(doi:10.1166/jbn.2009.1051).
Abstract
In order to explore the fullerene-lipid interaction, we have studied\nthe effects caused by C-60 on Large Unilamellar Vesicles (LUV). For\nthis purpose liposomes composed of L-a Phosphatidylcholine (PC) and\n1,2-dimyristoyl-sn-glycero-3-phospocholine (DMPC) and Cholesterol\n(Chol) in 2:1 molar ratio were used. The dispersions were characterized\nby means of Dynamic Light Scattering (DLS), zeta-potential measurements\nand Differential Scanning Calorimetry studies (DSC). The incorporation\nof C-60 into liposomes altered their physicochemical properties. A\nreduction to the mean diameter of the liposomes was observed when C-60\nwere incorporated, which might imply deformations on the lipid membrane\ninduced by fullerenes. An increase to the surface charge of the\nliposomes was noticed when C-60 molecules were present in the membrane\nproviding evidence of their successful incorporation into the liposomal\nbilayers. Finally the miscibility of liposomes with C-60 was\ninvestigated by DSC. Alterations occurred to the main transition of the\nliposomes when C-60 molecules were present in the membrane might be\nattributed to the penetration of the carbonaceous material into the\nlipid bilayers.
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Published date: 1 August 2009
Organisations:
Engineering Mats & Surface Engineerg Gp
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Local EPrints ID: 337798
URI: http://eprints.soton.ac.uk/id/eprint/337798
ISSN: 1550-7033
PURE UUID: 7605a868-89a6-46dc-8a35-943e74140e89
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Date deposited: 04 May 2012 10:28
Last modified: 15 Mar 2024 03:38
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Author:
Nikolaos Bouropoulos
Author:
Dimitrios G. Fatouros
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