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Interaction of fullerenes C60 with large unilamellar vesicles

Interaction of fullerenes C60 with large unilamellar vesicles
Interaction of fullerenes C60 with large unilamellar vesicles
In order to explore the fullerene-lipid interaction, we have studied\nthe effects caused by C-60 on Large Unilamellar Vesicles (LUV). For\nthis purpose liposomes composed of L-a Phosphatidylcholine (PC) and\n1,2-dimyristoyl-sn-glycero-3-phospocholine (DMPC) and Cholesterol\n(Chol) in 2:1 molar ratio were used. The dispersions were characterized\nby means of Dynamic Light Scattering (DLS), zeta-potential measurements\nand Differential Scanning Calorimetry studies (DSC). The incorporation\nof C-60 into liposomes altered their physicochemical properties. A\nreduction to the mean diameter of the liposomes was observed when C-60\nwere incorporated, which might imply deformations on the lipid membrane\ninduced by fullerenes. An increase to the surface charge of the\nliposomes was noticed when C-60 molecules were present in the membrane\nproviding evidence of their successful incorporation into the liposomal\nbilayers. Finally the miscibility of liposomes with C-60 was\ninvestigated by DSC. Alterations occurred to the main transition of the\nliposomes when C-60 molecules were present in the membrane might be\nattributed to the penetration of the carbonaceous material into the\nlipid bilayers.
1550-7033
416-420
Katsamenis, Orestis L.
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Bouropoulos, Nikolaos
fadadea1-2aa2-4cd9-a7e5-33ba790cd45f
Fatouros, Dimitrios G.
4a716c96-a8ba-4fbf-b3db-3b2a3a2794c4
Katsamenis, Orestis L.
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Bouropoulos, Nikolaos
fadadea1-2aa2-4cd9-a7e5-33ba790cd45f
Fatouros, Dimitrios G.
4a716c96-a8ba-4fbf-b3db-3b2a3a2794c4

Katsamenis, Orestis L., Bouropoulos, Nikolaos and Fatouros, Dimitrios G. (2009) Interaction of fullerenes C60 with large unilamellar vesicles. Journal of Biomedical Nanotechnology, 5 (4), 416-420. (doi:10.1166/jbn.2009.1051).

Record type: Article

Abstract

In order to explore the fullerene-lipid interaction, we have studied\nthe effects caused by C-60 on Large Unilamellar Vesicles (LUV). For\nthis purpose liposomes composed of L-a Phosphatidylcholine (PC) and\n1,2-dimyristoyl-sn-glycero-3-phospocholine (DMPC) and Cholesterol\n(Chol) in 2:1 molar ratio were used. The dispersions were characterized\nby means of Dynamic Light Scattering (DLS), zeta-potential measurements\nand Differential Scanning Calorimetry studies (DSC). The incorporation\nof C-60 into liposomes altered their physicochemical properties. A\nreduction to the mean diameter of the liposomes was observed when C-60\nwere incorporated, which might imply deformations on the lipid membrane\ninduced by fullerenes. An increase to the surface charge of the\nliposomes was noticed when C-60 molecules were present in the membrane\nproviding evidence of their successful incorporation into the liposomal\nbilayers. Finally the miscibility of liposomes with C-60 was\ninvestigated by DSC. Alterations occurred to the main transition of the\nliposomes when C-60 molecules were present in the membrane might be\nattributed to the penetration of the carbonaceous material into the\nlipid bilayers.

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Published date: 1 August 2009
Organisations: Engineering Mats & Surface Engineerg Gp

Identifiers

Local EPrints ID: 337798
URI: https://eprints.soton.ac.uk/id/eprint/337798
ISSN: 1550-7033
PURE UUID: 7605a868-89a6-46dc-8a35-943e74140e89
ORCID for Orestis L. Katsamenis: ORCID iD orcid.org/0000-0003-4367-4147

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Date deposited: 04 May 2012 10:28
Last modified: 06 Jun 2018 12:31

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