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Therapeutic uses of inorganic nitrite and nitrate: from the past to the future

Butler, Anthony R. and Feelisch, Martin (2008) Therapeutic uses of inorganic nitrite and nitrate: from the past to the future Circulation, 117, (16), pp. 2151-2159. (doi:10.1161/CIRCULATIONAHA.107.753814). (PMID:18427145).

Record type: Article

Abstract

Potential carcinogenic effects, blue baby syndrome, and occasional intoxications caused by nitrite, as well as the suspected health risks related to fertilizer overuse, contributed to the negative image that inorganic nitrite and nitrate have had for decades. Recent experimental studies related to the molecular interaction between nitrite and heme proteins in blood and tissues, the potential role of nitrite in hypoxic vasodilatation, and an unexpected protective action of nitrite against ischemia/reperfusion injury, however, paint a different picture and have led to a renewed interest in the physiological and pharmacological properties of nitrite and nitrate. The range of effects reported suggests that these simple oxyanions of nitrogen have a much richer profile of biological actions than hitherto assumed, and several efforts are currently underway to investigate possible beneficial effects in the clinical arena. We provide here a brief historical account of the medical uses of nitrite and nitrate over the centuries that may serve as a basis for a careful reassessment of the health implications of their exposure and intake and may inform investigations into their therapeutic potential in the future.

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More information

Published date: 22 April 2008
Keywords: cardiovascular diseases, drugs, history of medicine, nitric oxide, pharmacology
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 337823
URI: http://eprints.soton.ac.uk/id/eprint/337823
ISSN: 0009-7322
PURE UUID: 5c011149-90be-432f-babf-fdf04f42dbb2
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 04 May 2012 08:55
Last modified: 18 Jul 2017 06:00

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Contributors

Author: Anthony R. Butler
Author: Martin Feelisch ORCID iD

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