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Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury

Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury
Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury
These results provide evidence that site-specific targeting of eNOS gene therapy may be more advantageous in limiting MI-R injury and subsequent cardiac dysfunction.
gene therapy, myocardial infarction, eNOS, cardiomyocyte, endothelial, cardiac function, blood pressure
1079-5642
1517-1523
Elrod, John W.
4303169c-e01e-47e4-95c4-af80e7fe584f
Greer, James J.M.
82eac966-86bb-44ad-8155-9b8798179adb
Bryan, Nathan S.
709ff51c-c864-4862-9e3f-c5cfd3961025
Langston, Will
16b62bf8-b448-4088-b9a3-279048f629e8
Szot, Jeffrey F.
5d0a48d4-2927-4eee-9361-75ff79eb87f6
Gebregzlabher, Henock
c1da8584-d147-4c80-9c4b-0ad3840f55de
Janssens, Stefan
10ddf472-392d-4c79-ab7e-cda3aabe7232
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Lefer, David J.
0a35277a-930b-490a-b397-db94c7fb0a80
Elrod, John W.
4303169c-e01e-47e4-95c4-af80e7fe584f
Greer, James J.M.
82eac966-86bb-44ad-8155-9b8798179adb
Bryan, Nathan S.
709ff51c-c864-4862-9e3f-c5cfd3961025
Langston, Will
16b62bf8-b448-4088-b9a3-279048f629e8
Szot, Jeffrey F.
5d0a48d4-2927-4eee-9361-75ff79eb87f6
Gebregzlabher, Henock
c1da8584-d147-4c80-9c4b-0ad3840f55de
Janssens, Stefan
10ddf472-392d-4c79-ab7e-cda3aabe7232
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Lefer, David J.
0a35277a-930b-490a-b397-db94c7fb0a80

Elrod, John W., Greer, James J.M., Bryan, Nathan S., Langston, Will, Szot, Jeffrey F., Gebregzlabher, Henock, Janssens, Stefan, Feelisch, Martin and Lefer, David J. (2006) Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury. Arteriosclerosis, Thrombosis, and Vascular Biology, 26 (7), 1517-1523. (doi:10.1161/01.ATV.0000224324.52466.e6). (PMID:16645153)

Record type: Article

Abstract

These results provide evidence that site-specific targeting of eNOS gene therapy may be more advantageous in limiting MI-R injury and subsequent cardiac dysfunction.

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More information

Published date: July 2006
Keywords: gene therapy, myocardial infarction, eNOS, cardiomyocyte, endothelial, cardiac function, blood pressure
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 337832
URI: http://eprints.soton.ac.uk/id/eprint/337832
ISSN: 1079-5642
PURE UUID: cbcf1388-eb35-47eb-aa59-c1db710afda1
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 04 May 2012 13:27
Last modified: 15 Mar 2024 03:41

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Contributors

Author: John W. Elrod
Author: James J.M. Greer
Author: Nathan S. Bryan
Author: Will Langston
Author: Jeffrey F. Szot
Author: Henock Gebregzlabher
Author: Stefan Janssens
Author: Martin Feelisch ORCID iD
Author: David J. Lefer

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