Mechanisms of the antioxidant effects of nitric oxide

Wink, David A., Miranda, Katrina M., Espey, Michael G., Pluta, Ryzard M., Hewett, Sandra J., Colton, Carol, Vitek, Michael, Feelisch, Martin and Grisham, Mathew B. (2001) Mechanisms of the antioxidant effects of nitric oxide Antioxidants & Redox Signaling, 3, (2), pp. 203-213. (doi:10.1089/152308601300185179). (PMID:11396476).


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The Janus face of nitric oxide (NO) has prompted a debate as to whether NO plays a deleterious or protective role in tissue injury. There are a number of reactive nitrogen oxide species, such as N2O3 and ONOO-, that can alter critical cellular components under high local concentrations of NO. However, NO can also abate the oxidation chemistry mediated by reactive oxygen species such as H2O2 and O2- that occurs at physiological levels of NO. In addition to the antioxidant chemistry, NO protects against cell death mediated by H2O2, alkylhydroperoxides, and xanthine oxidase. The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. This review will address these aspects of the chemical biology of this multifaceted free radical and explore the beneficial effect of NO against oxidative stress.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1089/152308601300185179
ISSNs: 1523-0864 (print)
Organisations: Clinical & Experimental Sciences
ePrint ID: 337870
Date :
Date Event
April 2001Published
Date Deposited: 22 Jun 2012 13:58
Last Modified: 17 Apr 2017 17:13
Further Information:Google Scholar

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