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Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension

Preik, Michael, Kelm, Malte, Feelisch, Martin and Strauer, Bodo E. (1996) Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension Journal of Hypertension, 14, (7), pp. 903-908. (PMID:8818930).

Record type: Article

Abstract

Dilation of resistance arteries in response to infusion of nitric oxide donors is impaired in hypertensive patients and the degree of this impairment depends critically on the severity of arterial hypertension. The reduced effectiveness of nitric oxide appears to be independent of the class of nitric oxide donor and thus of the mode of intravascular nitric oxide generation. These findings are likely to have important implications not only for our understanding of the pathophysiological mechanisms of endothelial dysfunction but also for nitric oxide donor therapy in arterial hypertension.

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More information

Published date: July 1996
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 337891
URI: http://eprints.soton.ac.uk/id/eprint/337891
ISSN: 0263-6352
PURE UUID: ee3d7674-bd9e-44a3-801c-0dbe898caaa3
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 29 Jun 2012 14:07
Last modified: 18 Jul 2017 06:00

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Contributors

Author: Michael Preik
Author: Malte Kelm
Author: Martin Feelisch ORCID iD
Author: Bodo E. Strauer

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