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Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension

Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension
Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension
Dilation of resistance arteries in response to infusion of nitric oxide donors is impaired in hypertensive patients and the degree of this impairment depends critically on the severity of arterial hypertension. The reduced effectiveness of nitric oxide appears to be independent of the class of nitric oxide donor and thus of the mode of intravascular nitric oxide generation. These findings are likely to have important implications not only for our understanding of the pathophysiological mechanisms of endothelial dysfunction but also for nitric oxide donor therapy in arterial hypertension.
0263-6352
903-908
Preik, Michael
59d2d820-b12d-4020-a3a2-b89c636a8ba3
Kelm, Malte
db2bb062-32d7-4b50-9f65-8ba89ffa5f42
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Strauer, Bodo E.
7343fe67-ccf3-4079-94a0-ea6238979951
Preik, Michael
59d2d820-b12d-4020-a3a2-b89c636a8ba3
Kelm, Malte
db2bb062-32d7-4b50-9f65-8ba89ffa5f42
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Strauer, Bodo E.
7343fe67-ccf3-4079-94a0-ea6238979951

Preik, Michael, Kelm, Malte, Feelisch, Martin and Strauer, Bodo E. (1996) Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension. Journal of Hypertension, 14 (7), 903-908. (PMID:8818930)

Record type: Article

Abstract

Dilation of resistance arteries in response to infusion of nitric oxide donors is impaired in hypertensive patients and the degree of this impairment depends critically on the severity of arterial hypertension. The reduced effectiveness of nitric oxide appears to be independent of the class of nitric oxide donor and thus of the mode of intravascular nitric oxide generation. These findings are likely to have important implications not only for our understanding of the pathophysiological mechanisms of endothelial dysfunction but also for nitric oxide donor therapy in arterial hypertension.

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More information

Published date: July 1996
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 337891
URI: https://eprints.soton.ac.uk/id/eprint/337891
ISSN: 0263-6352
PURE UUID: ee3d7674-bd9e-44a3-801c-0dbe898caaa3
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 29 Jun 2012 14:07
Last modified: 06 Jun 2018 12:29

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