The University of Southampton
University of Southampton Institutional Repository

Preferential dilation of large coronary microvessels by the mononitrates SPM-4744 and SPM-5185

Wang, Steven Y., Feelisch, Martin, Harrison, David G. and Sellke, Frank W. (1996) Preferential dilation of large coronary microvessels by the mononitrates SPM-4744 and SPM-5185 Journal of Cardiovascular Pharmacology, 27, (4), pp. 587-593. (PMID:8847878).

Record type: Article


A novel aspect of the pharmacodynamic action of nitroglycerin is that it is a potent dilator of larger coronary arteries, yet it dilates smaller coronary microvessels submaximally and only in high concentrations. We sought to determine whether this property was shared by other organic nitrates. The effects of two mononitrates. SPM-4744 and SPM-5185 (the latter of which possesses a thioester in its structure), on coronary microvessels of different sizes were studied. Large (200-microns diameter) and small ( < 100-microns diameter) porcine coronary microvessels were studied in vitro while pressurized in a no-flow state. After constriction with the thromboxane analogue U46619, maximal dilations (as a percent of preconstricted tone at the highest applied concentration, 10 microM) of small coronary microvessels were 18 +/- 3 and 16 = 2% in response to SPM-4744 and SPM-5185, respectively. The dilations of larger coronary microvessels to SPM-4744 and SPM-5185 were 55 +/- 5 and 43 +/- 6%, respectively (both p < 0.001 vs. the small vessel responses). This pattern of differential vasodilatation of large and small coronary microvessels was similar to that produced by nitroglycerin. In contrast, sodium nitroprusside produced equivalent degrees of vasodilation of small and large coronary microvessels. Additional experiments demonstrated that both SPM compounds produced dilation of the coronary microcirculation in isolated rat heart and relaxed isolated segments of rat aortic rings only in high ( > or = 1 microM) concentrations. These data demonstrate that the organic mononitrates are similar to nitroglycerin in their selectivity for larger coronary microvessels and produce only minimal dilation of coronary microvessels < 100 microM in diameter.

PDF 1996 Wang-Cardiovasc Pharmacol.PDF - Other
Download (986kB)
PDF 1996 Preik-J Hypertens.PDF - Other
Download (855kB)

More information

Published date: April 1996
Keywords: organic nitrates, sodium nitroprusside, vasodilatation
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 337892
ISSN: 0160-2446
PURE UUID: af4b286d-c47c-4d4c-9373-662ebc2ee269
ORCID for Martin Feelisch: ORCID iD

Catalogue record

Date deposited: 29 Jun 2012 14:12
Last modified: 18 Jul 2017 06:00

Export record


Author: Steven Y. Wang
Author: Martin Feelisch ORCID iD
Author: David G. Harrison
Author: Frank W. Sellke

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.