Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels


Ney, P. and Feelisch, M. (1995) Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels Agents and Actions. Supplements, 45, pp. 71-76. (PMID:7536384).

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Description/Abstract

This study was undertaken to investigate the possible involvement of K+ channels in PGE1-mediated vasodilatation. The increase in coronary flow elicited by PGE1 in isolated working rat hearts was attenuated by phentolamine and glibenclamide, inhibitors of ATP-regulated K+ channels, whereas apamin and charybdotoxin, inhibitors of calcium-activated K+ channels, were ineffective. In the anaesthetized rat, the duration of the hypotensive action of PGE1 was markedly attenuated by glibenclamide. It is concluded that the vasodilatory action of PGE1 in the coronary and systemic circulation of the rat is, at least in part, mediated via an opening of ATP-sensitive K+ channels.

Item Type: Article
ISSNs: 0379-0363 (print)
Subjects:
Organisations: Clinical & Experimental Sciences
ePrint ID: 337901
Date :
Date Event
18 May 1995Published
Date Deposited: 06 Jul 2012 15:46
Last Modified: 17 Apr 2017 17:13
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/337901

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