Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels
Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels
This study was undertaken to investigate the possible involvement of K+ channels in PGE1-mediated vasodilatation. The increase in coronary flow elicited by PGE1 in isolated working rat hearts was attenuated by phentolamine and glibenclamide, inhibitors of ATP-regulated K+ channels, whereas apamin and charybdotoxin, inhibitors of calcium-activated K+ channels, were ineffective. In the anaesthetized rat, the duration of the hypotensive action of PGE1 was markedly attenuated by glibenclamide. It is concluded that the vasodilatory action of PGE1 in the coronary and systemic circulation of the rat is, at least in part, mediated via an opening of ATP-sensitive K+ channels.
71-76
Ney, P.
e93e080e-15cc-4062-ae08-f91c0d36a3ba
Feelisch, M.
8c1b9965-8614-4e85-b2c6-458a2e17eafd
18 May 1995
Ney, P.
e93e080e-15cc-4062-ae08-f91c0d36a3ba
Feelisch, M.
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Ney, P. and Feelisch, M.
(1995)
Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels.
Agents and Actions. Supplements, 45, .
(PMID:7536384)
Abstract
This study was undertaken to investigate the possible involvement of K+ channels in PGE1-mediated vasodilatation. The increase in coronary flow elicited by PGE1 in isolated working rat hearts was attenuated by phentolamine and glibenclamide, inhibitors of ATP-regulated K+ channels, whereas apamin and charybdotoxin, inhibitors of calcium-activated K+ channels, were ineffective. In the anaesthetized rat, the duration of the hypotensive action of PGE1 was markedly attenuated by glibenclamide. It is concluded that the vasodilatory action of PGE1 in the coronary and systemic circulation of the rat is, at least in part, mediated via an opening of ATP-sensitive K+ channels.
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Published date: 18 May 1995
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 337901
URI: http://eprints.soton.ac.uk/id/eprint/337901
ISSN: 0379-0363
PURE UUID: 58b2f2e5-7a7d-4727-8807-815f18a36da4
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Date deposited: 06 Jul 2012 15:46
Last modified: 15 Mar 2024 03:41
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Author:
P. Ney
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