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Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels

Record type: Article

This study was undertaken to investigate the possible involvement of K+ channels in PGE1-mediated vasodilatation. The increase in coronary flow elicited by PGE1 in isolated working rat hearts was attenuated by phentolamine and glibenclamide, inhibitors of ATP-regulated K+ channels, whereas apamin and charybdotoxin, inhibitors of calcium-activated K+ channels, were ineffective. In the anaesthetized rat, the duration of the hypotensive action of PGE1 was markedly attenuated by glibenclamide. It is concluded that the vasodilatory action of PGE1 in the coronary and systemic circulation of the rat is, at least in part, mediated via an opening of ATP-sensitive K+ channels.

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Citation

Ney, P. and Feelisch, M. (1995) Vasodilator effects of PGE1 in the coronary and systemic circulation of the rat are mediated by ATP-sensitive potassium (K+) channels Agents and Actions. Supplements, 45, pp. 71-76. (PMID:7536384).

More information

Published date: 18 May 1995
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 337901
URI: http://eprints.soton.ac.uk/id/eprint/337901
ISSN: 0379-0363
PURE UUID: 58b2f2e5-7a7d-4727-8807-815f18a36da4
ORCID for M. Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 06 Jul 2012 15:46
Last modified: 18 Jul 2017 06:00

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Contributors

Author: P. Ney
Author: M. Feelisch ORCID iD

University divisions

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