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Release of endothelium derived nitric oxide in relation to pressure and flow

Release of endothelium derived nitric oxide in relation to pressure and flow
Release of endothelium derived nitric oxide in relation to pressure and flow
(1) The rate of NO release from endothelial cells increases when flow is enhanced. (2) Endothelial cells possess a high capacity for NO production, permitting a rapid adjustment of NO release to changes in flow. (3) The rate of NO release is not causally related to changes in perfusion pressure.
endothelium derived relaxing factor, nitric oxide, hypertension, thrombosis
0008-6363
831-836
Kelm, Malte
db2bb062-32d7-4b50-9f65-8ba89ffa5f42
Feelisch, M
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Deussen, Andreas
cc66975e-8cf4-40fd-a531-bcf52af65dc2
Strauer, Bodo E.
7343fe67-ccf3-4079-94a0-ea6238979951
Schrader, Jürgen
fb34ccfe-a295-411f-9ebb-f15b5ed4bad8
Kelm, Malte
db2bb062-32d7-4b50-9f65-8ba89ffa5f42
Feelisch, M
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Deussen, Andreas
cc66975e-8cf4-40fd-a531-bcf52af65dc2
Strauer, Bodo E.
7343fe67-ccf3-4079-94a0-ea6238979951
Schrader, Jürgen
fb34ccfe-a295-411f-9ebb-f15b5ed4bad8

Kelm, Malte, Feelisch, M, Deussen, Andreas, Strauer, Bodo E. and Schrader, Jürgen (1991) Release of endothelium derived nitric oxide in relation to pressure and flow. Cardiovascular Research, 25 (10), 831-836. (doi:10.1093/cvr/25.10.831). (PMID:1747876)

Record type: Article

Abstract

(1) The rate of NO release from endothelial cells increases when flow is enhanced. (2) Endothelial cells possess a high capacity for NO production, permitting a rapid adjustment of NO release to changes in flow. (3) The rate of NO release is not causally related to changes in perfusion pressure.

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More information

Published date: October 1991
Keywords: endothelium derived relaxing factor, nitric oxide, hypertension, thrombosis
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 337915
URI: https://eprints.soton.ac.uk/id/eprint/337915
ISSN: 0008-6363
PURE UUID: f053fc95-12c4-4954-af27-769c5fe70b71
ORCID for M Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 28 Jun 2012 15:28
Last modified: 06 Jun 2018 12:29

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Contributors

Author: Malte Kelm
Author: M Feelisch ORCID iD
Author: Andreas Deussen
Author: Bodo E. Strauer
Author: Jürgen Schrader

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