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Multinational evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E initiative

Record type: Article

Methods: 697 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2008–9 consisting of three separate rounds of discussions and modified Delphi votes. In the first round 10 clinical questions were selected. A bibliographic team systematically searched Medline, Embase, the Cochrane Library and ACR/EULAR 2007–2008 meeting abstracts. Relevant articles were reviewed for quality assessment, data extraction and synthesis. In the second round each country elaborated a set of national recommendations. Finally, multinational recommendations were formulated and agreement among the participants and the potential impact on their clinical practice was assessed.

Results: A total of 39 756 references were identified, of which 250 were systematically reviewed. Ten multinational key recommendations about the investigation and follow-up of UPIA were formulated. One recommendation addressed differential diagnosis and investigations prior to establishing the operational diagnosis of UPIA, seven recommendations related to the diagnostic and prognostic value of clinical and laboratory assessments in established UPIA (history and physical examination, acute phase reactants, autoantibodies, radiographs, MRI and ultrasound, genetic markers and synovial biopsy), one recommendation highlighted predictors of persistence (chronicity) and the final recommendation addressed monitoring of clinical disease activity in UPIA.

Conclusions: Ten recommendations on how to investigate and follow-up UPIA in the clinical setting were developed. They are evidence-based and supported by a large panel of rheumatologists, thus enhancing their validity and practical use.

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Citation

Machado, P., Castrejon, I., Katchamart, W., Koevoets, R., Kuriya, B., Schoels, M., Silva-Fernández, L., Thevissen, K., Vercoutere, W., Villeneuve, E., Aletaha, D., Carmona, L., Landewe, R., van der Heijde, D., Bijlsma, J.W.J., Bykerk, V., Canhão, H., Catrina, A.I., Durez, P., Edwards, C.J., Mjaavatten, M.D., Leeb, B.F., Losada, B., Martín-Mola, E.M., Martinez-Osuna, P., Montecucco, C., Müller-Ladner, U., Østergaard, M., Sheane, B., Xavier, R.M., Zochling, J. and Bombardier, C. (2011) Multinational evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E initiative Annals of the Rheumatic Diseases, 70, (1), pp. 15-24. (doi:10.1136/ard.2010.130625). (PMID:20724311).

More information

e-pub ahead of print date: 19 August 2010
Published date: January 2011
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 338300
URI: http://eprints.soton.ac.uk/id/eprint/338300
ISSN: 0003-4967
PURE UUID: a9ce4b29-e09b-426e-b3d1-29fca61e2c14

Catalogue record

Date deposited: 11 May 2012 15:50
Last modified: 18 Jul 2017 05:58

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Contributors

Author: P. Machado
Author: I. Castrejon
Author: W. Katchamart
Author: R. Koevoets
Author: B. Kuriya
Author: M. Schoels
Author: L. Silva-Fernández
Author: K. Thevissen
Author: W. Vercoutere
Author: E. Villeneuve
Author: D. Aletaha
Author: L. Carmona
Author: R. Landewe
Author: D. van der Heijde
Author: J.W.J. Bijlsma
Author: V. Bykerk
Author: H. Canhão
Author: A.I. Catrina
Author: P. Durez
Author: C.J. Edwards
Author: M.D. Mjaavatten
Author: B.F. Leeb
Author: B. Losada
Author: E.M. Martín-Mola
Author: P. Martinez-Osuna
Author: C. Montecucco
Author: U. Müller-Ladner
Author: M. Østergaard
Author: B. Sheane
Author: R.M. Xavier
Author: J. Zochling
Author: C. Bombardier

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