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Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring

Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring
Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring
These results demonstrate for the first time that the preimplantation embryo in vivo is sensitive to maternal systemic inflammation, with effects on blastocyst cell lineage allocation and consequences for behaviour, adiposity and innate immune response in adult offspring. Critically, we identify a novel mechanism mediated through maternal-embryonic interactions that confers plasticity in the development of the innate immune system, which is potentially important in setting postnatal tolerance to environmental pathogens. Our study extends the concept of developmental programming of health and disease to include maternal health at the time of conception
1741-7007
49-61
Williams, Charlotte L
0a851f08-58c8-4d7c-a757-825387a12e62
Teeling, Jessica L
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Fleming, Tom P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Williams, Charlotte L
0a851f08-58c8-4d7c-a757-825387a12e62
Teeling, Jessica L
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Fleming, Tom P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03

Williams, Charlotte L, Teeling, Jessica L, Perry, V. Hugh and Fleming, Tom P. (2011) Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring. BMC Biology, 9, 49-61. (doi:10.1186/1741-7007-9-49). (PMID:21771319)

Record type: Article

Abstract

These results demonstrate for the first time that the preimplantation embryo in vivo is sensitive to maternal systemic inflammation, with effects on blastocyst cell lineage allocation and consequences for behaviour, adiposity and innate immune response in adult offspring. Critically, we identify a novel mechanism mediated through maternal-embryonic interactions that confers plasticity in the development of the innate immune system, which is potentially important in setting postnatal tolerance to environmental pathogens. Our study extends the concept of developmental programming of health and disease to include maternal health at the time of conception

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49 - Accepted Manuscript
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Published date: 2011
Organisations: Biomedicine

Identifiers

Local EPrints ID: 338339
URI: https://eprints.soton.ac.uk/id/eprint/338339
ISSN: 1741-7007
PURE UUID: 35865654-fe50-4f79-8541-99a404244249
ORCID for Jessica L Teeling: ORCID iD orcid.org/0000-0003-4004-7391

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Date deposited: 16 May 2012 09:12
Last modified: 29 Aug 2019 00:43

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