Age-related macular degeneration
Age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world. Despite recent advances in treatment, AMD causes considerable morbidity. For the non-ophthalmologist, a brief background on retinal structure is provided, followed by a description of the characteristic changes seen in AMD. Subsequently the typical clinical features of AMD are discussed with an outline of present management, followed by the current theories of AMD pathogenesis. The similarities between AMD and another neurodegenerative disease are then highlighted. Finally, we review the on-going clinical trials of potential treatments for the future. Since it is clear that multiple risk factors are involved in the pathogenesis of AMD, a multi-faceted approach will most likely be required in order to prevent further patients progressing to blindness as a result of this devastating condition.
15-36
Khandhadia, Sam
a84355f9-8dd3-4377-864f-27fa059ad847
Cherry, Jocelyn
e0eeabee-b656-42b0-a53d-d04a7d6dc628
Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
2012
Khandhadia, Sam
a84355f9-8dd3-4377-864f-27fa059ad847
Cherry, Jocelyn
e0eeabee-b656-42b0-a53d-d04a7d6dc628
Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Abstract
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world. Despite recent advances in treatment, AMD causes considerable morbidity. For the non-ophthalmologist, a brief background on retinal structure is provided, followed by a description of the characteristic changes seen in AMD. Subsequently the typical clinical features of AMD are discussed with an outline of present management, followed by the current theories of AMD pathogenesis. The similarities between AMD and another neurodegenerative disease are then highlighted. Finally, we review the on-going clinical trials of potential treatments for the future. Since it is clear that multiple risk factors are involved in the pathogenesis of AMD, a multi-faceted approach will most likely be required in order to prevent further patients progressing to blindness as a result of this devastating condition.
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Published date: 2012
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 338837
URI: http://eprints.soton.ac.uk/id/eprint/338837
ISSN: 0065-2598
PURE UUID: 0ee2b0d1-4dcb-4bb1-bd1c-b275fe4f208c
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Date deposited: 17 May 2012 15:20
Last modified: 15 Mar 2024 03:15
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Author:
Sam Khandhadia
Author:
Jocelyn Cherry
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