Outcome of childhood ulcerative colitis at 2 years
Outcome of childhood ulcerative colitis at 2 years
Aim: Ulcerative Colitis (UC) has an incidence of 1.4 per 100 000 in childhood. There is a paucity of data regarding outcome particularly with the increased use of early immunosuppression. This study reviews outcome at 2 years in a cohort with UC referred to a single centre.
Method: Patients were recruited on the basis of a diagnosis made between 2000 and 2003 as a consecutive cohort. All had UC according to standard clinicopathological criteria. Children with indeterminate colitis were excluded. Follow-up data was collected at 2 years by case notes review.
Results: Thirty-two children are reported. The median age at diagnosis was 11 years (range 2–16). All were treated with corticosteroids and 5-ASA derivatives at diagnosis. The majority of patients (94%, 30/32) received more than one course of steroids. By 2 years azathioprine use was high with 75% (24/32) of patients on treatment for steroid-dependent disease. There were 6 extra-intestinal manifestations and 8 disease related complications occurring in 12 patients (38%). The colectomy rate was 9% (3/32) for unresponsive disease.
Conclusion: There is a high need for Azathioprine in childhood UC. Colectomy rate at 2 years was around 10%. Extra-intestinal manifestations and disease related complications are common.
azathioprine, corticosteroids, surgery, ulcerative colitis
1790-1793
Howarth, L.J.
b154c116-6b28-4371-b764-23fbe49bd495
Wiskin, A.E.
2f0070e1-9a80-4856-8c5f-0c91c3d06260
Griffiths, D.M.
eb78d30d-4889-49a0-9cec-45cf1abd0cef
Afzal, D.M.
dd64cbc0-9400-4b12-bc51-43f3e7d39f4c
Beattie, R.M.
977a2f68-2bcf-4436-87e7-28a39952adda
December 2007
Howarth, L.J.
b154c116-6b28-4371-b764-23fbe49bd495
Wiskin, A.E.
2f0070e1-9a80-4856-8c5f-0c91c3d06260
Griffiths, D.M.
eb78d30d-4889-49a0-9cec-45cf1abd0cef
Afzal, D.M.
dd64cbc0-9400-4b12-bc51-43f3e7d39f4c
Beattie, R.M.
977a2f68-2bcf-4436-87e7-28a39952adda
Howarth, L.J., Wiskin, A.E., Griffiths, D.M., Afzal, D.M. and Beattie, R.M.
(2007)
Outcome of childhood ulcerative colitis at 2 years.
Acta Paediatrica, 96 (12), .
(doi:10.1111/j.1651-2227.2007.00515.x).
(PMID:17971192)
Abstract
Aim: Ulcerative Colitis (UC) has an incidence of 1.4 per 100 000 in childhood. There is a paucity of data regarding outcome particularly with the increased use of early immunosuppression. This study reviews outcome at 2 years in a cohort with UC referred to a single centre.
Method: Patients were recruited on the basis of a diagnosis made between 2000 and 2003 as a consecutive cohort. All had UC according to standard clinicopathological criteria. Children with indeterminate colitis were excluded. Follow-up data was collected at 2 years by case notes review.
Results: Thirty-two children are reported. The median age at diagnosis was 11 years (range 2–16). All were treated with corticosteroids and 5-ASA derivatives at diagnosis. The majority of patients (94%, 30/32) received more than one course of steroids. By 2 years azathioprine use was high with 75% (24/32) of patients on treatment for steroid-dependent disease. There were 6 extra-intestinal manifestations and 8 disease related complications occurring in 12 patients (38%). The colectomy rate was 9% (3/32) for unresponsive disease.
Conclusion: There is a high need for Azathioprine in childhood UC. Colectomy rate at 2 years was around 10%. Extra-intestinal manifestations and disease related complications are common.
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e-pub ahead of print date: 30 October 2007
Published date: December 2007
Keywords:
azathioprine, corticosteroids, surgery, ulcerative colitis
Organisations:
Human Development & Health
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Local EPrints ID: 338922
URI: http://eprints.soton.ac.uk/id/eprint/338922
ISSN: 0803-5253
PURE UUID: 9d90069c-6607-408f-9599-5e3de8138f7a
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Date deposited: 31 May 2012 16:39
Last modified: 14 Mar 2024 11:07
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Author:
L.J. Howarth
Author:
A.E. Wiskin
Author:
D.M. Griffiths
Author:
D.M. Afzal
Author:
R.M. Beattie
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