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The scope of the crustacean immune system for disease control

The scope of the crustacean immune system for disease control
The scope of the crustacean immune system for disease control
The culture or wild capture of marine and freshwater shellfish, including crustaceans, is without doubt a key source of protein for a burgeoning world population. Historically the expansion of aquaculture has, however, been accompanied by the increased incidence of economically significant diseases, most notably of viral and bacterial origin. Since the late 1970s great progress has been made in our understanding of the generalized protostome innate immune system. Distinct pathways, pathogen receptor proteins and effector molecules have since been identified that are not ancestral or homologous to those of the deuterostomes, including vertebrates. Within the past decade progress has accelerated with the rapid characterisation of new classes of recognition proteins, immune effectors and regulatory pathways. This paper provides a broad overview of our current understanding of invertebrate immunology, taking the crustacean decapod immune system as its focus. Recent developments in the field are described briefly and their implications and potential considered. These advances offer fundamental new insights in our efforts to understand disease in cultured populations and also to develop knowledge of environmental effects on host/pathogen interactions within a fishery context. Of course, challenges do remain, including the lack of an immortal cell line and the limited publically-available genomic resources. These are considered in this review as priorities for future research effort. With the continued application of more insightful technologies, coupled with associated investment, it is expected that the speed at which some of these issues are resolved will accelerate.
Crustacean, Immunity, Disease, Aquaculture, Virus, Bacteria
0022-2011
251-260
Hauton, Chris
7706f6ba-4497-42b2-8c6d-00df81676331
Hauton, Chris
7706f6ba-4497-42b2-8c6d-00df81676331

Hauton, Chris (2012) The scope of the crustacean immune system for disease control. Journal of Invertebrate Pathology, 110 (2), 251-260. (doi:10.1016/j.jip.2012.03.005).

Record type: Article

Abstract

The culture or wild capture of marine and freshwater shellfish, including crustaceans, is without doubt a key source of protein for a burgeoning world population. Historically the expansion of aquaculture has, however, been accompanied by the increased incidence of economically significant diseases, most notably of viral and bacterial origin. Since the late 1970s great progress has been made in our understanding of the generalized protostome innate immune system. Distinct pathways, pathogen receptor proteins and effector molecules have since been identified that are not ancestral or homologous to those of the deuterostomes, including vertebrates. Within the past decade progress has accelerated with the rapid characterisation of new classes of recognition proteins, immune effectors and regulatory pathways. This paper provides a broad overview of our current understanding of invertebrate immunology, taking the crustacean decapod immune system as its focus. Recent developments in the field are described briefly and their implications and potential considered. These advances offer fundamental new insights in our efforts to understand disease in cultured populations and also to develop knowledge of environmental effects on host/pathogen interactions within a fishery context. Of course, challenges do remain, including the lack of an immortal cell line and the limited publically-available genomic resources. These are considered in this review as priorities for future research effort. With the continued application of more insightful technologies, coupled with associated investment, it is expected that the speed at which some of these issues are resolved will accelerate.

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HAUTON_post-print_10.1016_j.jip.2012.03.005.pdf - Accepted Manuscript
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More information

Published date: 17 May 2012
Keywords: Crustacean, Immunity, Disease, Aquaculture, Virus, Bacteria
Organisations: Ocean Biochemistry & Ecosystems

Identifiers

Local EPrints ID: 339004
URI: http://eprints.soton.ac.uk/id/eprint/339004
ISSN: 0022-2011
PURE UUID: 2818b10f-0b82-4dce-8b09-ecf02b8c12f8
ORCID for Chris Hauton: ORCID iD orcid.org/0000-0002-2313-4226

Catalogue record

Date deposited: 21 May 2012 08:28
Last modified: 15 Mar 2024 02:52

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