The University of Southampton
University of Southampton Institutional Repository

Risk of fracture with thiazolidinediones: disease or drugs?

Record type: Article

The use of thiazolidinediones (TZDs) has been associated with an increased fracture risk. In addition, type 2 diabetes mellitus (T2DM) has been linked with fracture. We evaluated to what extent the association between TZD use and fracture risk is related to the drug or to the underlying disease. We conducted a population-based cohort study using the Danish National Health Registers (1996–2007), which link pharmacy data to the national hospital registry. Oral antidiabetic users (n = 180,049) were matched 1:3 by year of birth and sex to nonusers. Cox proportional hazards models were used to estimate hazard ratios (HRs) of fracture. Time-dependent adjustments were made for age, comorbidity, and drug use. We created a proxy indicator for the severity of disease. The first stage was defined as current use of either a biguanide or a sulfonyluerum, the second stage as current use of a biguanide and a sulfonyluerum at the same time, the third stage as patients using TZDs, and the fourth stage as patients using insulin. The risk of osteoporotic fracture was increased 1.3-fold for stages 3 and 4 compared with controls. Risk with current TZD use (stage 3 HR = 1.27, 95% CI 1.06–1.52) and risk with current use of insulin (stage 4 HR = 1.25, 95% CI 1.20–1.31) were similar. In the first (HR = 1.15, 95% CI 1.13–1.18) and second (HR = 1.00, 95% CI 0.96–1.04) stages risks were lower. Risk of osteoporotic fracture was similar for TZD users and insulin users. When studying fracture risk with TZDs, the underlying T2DM should be taken into account.

Full text not available from this repository.

Citation

Bazelier, Marloes T., Vestergaard, Peter, Gallagher, Arlene M., van Staa, Tjeerd-Pieter, Cooper, Cyrus, Leufkens, Hubert G. M. and de Vries, Frank (2012) Risk of fracture with thiazolidinediones: disease or drugs? Calcified Tissue International, 90, (6), pp. 450-457. (doi:10.1007/s00223-012-9591-8). (PMID:22488176).

More information

Published date: June 2012
Keywords: thiazolidinedione, type 2 diabetes mellitus, fracture risk, osteoporosis
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 339042
URI: http://eprints.soton.ac.uk/id/eprint/339042
ISSN: 0171-967X
PURE UUID: 65cfdaf9-8150-494b-b484-6610909a8514

Catalogue record

Date deposited: 22 May 2012 11:19
Last modified: 18 Jul 2017 05:55

Export record

Altmetrics

Contributors

Author: Marloes T. Bazelier
Author: Peter Vestergaard
Author: Arlene M. Gallagher
Author: Tjeerd-Pieter van Staa
Author: Cyrus Cooper
Author: Hubert G. M. Leufkens
Author: Frank de Vries

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×