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Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in elderly men: MrOS

Javaid, M.Kassim, Prieto-Alhambra, Daniel, Lui, Li-Yung, Cawthorn, Peggy, Arden, Nigel K., Lang, Thomas, Lane, Nancy E., Orwoll, Eric, Barrett-Conner, Elizabeth, Nevitt, Michael C., Cooper, Cyrus and Cummings, Steven R. (2011) Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in elderly men: MrOS Journal of Bone and Mineral Research, 26, (8), pp. 1802-1807. (doi:10.1002/jbmr.411). (PMID:21509824).

Record type: Article


The mechanism whereby poor intrauterine growth increases risk of adult hip fracture is unclear. We report the association between birth weight and proximal femoral geometry and density in community-dwelling elderly men. We used self-reported birth weight, measured adult height and weight and proximal femoral quantitative computed tomography (QCT) measurements of femoral neck axis length, cross-sectional area, and volumetric BMD (vBMD) among the participants in the Osteoporotic Fractures in Men (MrOS), a cohort study of community-dwelling US men aged 65 and older. We compared men with birth weight <7 pounds (lower birth weight [LBW]; n = 501) and ? 9 pounds (higher birth weight [HBW]; n = 262) with those weighing 7-8.9 pounds (medium birth weight [MBW], referent group; n = 1068) using linear regression adjusting for current age, height, and BMI. The mean age of the 1831 men who had both birth weight and QCT measurements was 73 years (SD 5.9). Compared with the referent MBW, HBW men had concordantly longer femoral neck (+0.16 SD; p =?.028) and cross-sectional area (+0.24 SD, p =?.001). LBW men had a smaller cross-sectional (-0.26 SD, p <?.001) but longer femoral neck for their height (+0.11 SD, p =?.05). Neither cortical nor trabecular vBMD at the femoral neck was associated with birth weight. These findings support the hypothesis that the skeletal envelope, but not density, is set, in part, at birth. Further research exploring the association between early developmental factors and lifetime fracture risk is needed and may inform primary preventative strategies for fracture prevention.

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Published date: August 2011
Organisations: Faculty of Health Sciences


Local EPrints ID: 339133
ISSN: 0884-0431
PURE UUID: a8884f1c-a882-4d8a-a1c3-9e7986fc47b1
ORCID for Cyrus Cooper: ORCID iD

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Date deposited: 23 May 2012 13:02
Last modified: 18 Jul 2017 05:54

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Author: M.Kassim Javaid
Author: Daniel Prieto-Alhambra
Author: Li-Yung Lui
Author: Peggy Cawthorn
Author: Nigel K. Arden
Author: Thomas Lang
Author: Nancy E. Lane
Author: Eric Orwoll
Author: Elizabeth Barrett-Conner
Author: Michael C. Nevitt
Author: Cyrus Cooper ORCID iD
Author: Steven R. Cummings

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