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Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma

Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma
Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma
Asthma is a heterogeneous disorder hallmarked by chronic inflammation in the respiratory system. Exacerbations of asthma are correlated with respiratory infections. Considering the implication of interferon regulatory factor 5 (IRF5) in innate and adaptive immunity, we investigated the preferential transmission patterns of ten IRF5 gene polymorphisms in two asthmatic family cohorts. A common IRF5 haplotype was found to be associated with asthma and the severity of asthmatic symptoms. Stratified analysis of subgroups of asthmatic individuals revealed that the associations were more pronounced in nonatopic asthmatic individuals. In addition, the risk alleles of IRF5 polymorphisms for asthma were almost completely opposite to those for autoimmune disorders. Our study provides the first evidence of association between IRF5 and asthma, and sheds light on the related but potentially distinct roles of IRF5 alleles in the pathogenesis of asthma and autoimmune disorders.
0378-1119
220-225
Wang, Chuan
5a476ee9-4794-4e53-9de2-6c296a2215e6
Rose-Zerilli, Matthew J.
08b3afa4-dbc2-4c0d-a852-2a9f33431199
Koppelman, Gerard H.
8d04aab8-5795-4e62-b64a-de7e368c0d1d
Sandling, Johanna K.
bbad0465-5af2-49cc-b944-849f13e16d82
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Postma, Dirkje S.
23c1567d-a264-48a1-9ab4-01beda374e42
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Bours, Vincent
80a1c517-c2cd-45a6-a078-3248033e5bab
Syvänen, Ann-Christine
64934bdb-6f33-4d96-9ec8-b995a54745f5
Dideberg, Vinciane
499c80dc-46a0-4fe7-9235-26dd6e3a2025
Wang, Chuan
5a476ee9-4794-4e53-9de2-6c296a2215e6
Rose-Zerilli, Matthew J.
08b3afa4-dbc2-4c0d-a852-2a9f33431199
Koppelman, Gerard H.
8d04aab8-5795-4e62-b64a-de7e368c0d1d
Sandling, Johanna K.
bbad0465-5af2-49cc-b944-849f13e16d82
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Postma, Dirkje S.
23c1567d-a264-48a1-9ab4-01beda374e42
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Bours, Vincent
80a1c517-c2cd-45a6-a078-3248033e5bab
Syvänen, Ann-Christine
64934bdb-6f33-4d96-9ec8-b995a54745f5
Dideberg, Vinciane
499c80dc-46a0-4fe7-9235-26dd6e3a2025

Wang, Chuan, Rose-Zerilli, Matthew J., Koppelman, Gerard H., Sandling, Johanna K., Holloway, John W., Postma, Dirkje S., Holgate, Stephen T., Bours, Vincent, Syvänen, Ann-Christine and Dideberg, Vinciane (2012) Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma. Gene, 504 (2), 220-225. (doi:10.1016/j.gene.2012.05.021).

Record type: Article

Abstract

Asthma is a heterogeneous disorder hallmarked by chronic inflammation in the respiratory system. Exacerbations of asthma are correlated with respiratory infections. Considering the implication of interferon regulatory factor 5 (IRF5) in innate and adaptive immunity, we investigated the preferential transmission patterns of ten IRF5 gene polymorphisms in two asthmatic family cohorts. A common IRF5 haplotype was found to be associated with asthma and the severity of asthmatic symptoms. Stratified analysis of subgroups of asthmatic individuals revealed that the associations were more pronounced in nonatopic asthmatic individuals. In addition, the risk alleles of IRF5 polymorphisms for asthma were almost completely opposite to those for autoimmune disorders. Our study provides the first evidence of association between IRF5 and asthma, and sheds light on the related but potentially distinct roles of IRF5 alleles in the pathogenesis of asthma and autoimmune disorders.

Full text not available from this repository.

More information

Accepted/In Press date: 18 May 2012
Published date: August 2012
Organisations: Cancer Sciences, Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 339167
URI: https://eprints.soton.ac.uk/id/eprint/339167
ISSN: 0378-1119
PURE UUID: fe1712be-58df-49e6-82f2-830a358653e5
ORCID for Matthew J. Rose-Zerilli: ORCID iD orcid.org/0000-0002-1064-5350
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 23 May 2012 16:05
Last modified: 20 Jul 2019 01:14

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