The University of Southampton
University of Southampton Institutional Repository

Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma

Wang, Chuan, Rose-Zerilli, Matthew J., Koppelman, Gerard H., Sandling, Johanna K., Holloway, John W., Postma, Dirkje S., Holgate, Stephen T., Bours, Vincent, Syvänen, Ann-Christine and Dideberg, Vinciane (2012) Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma Gene, 504, (2), pp. 220-225. (doi:10.1016/j.gene.2012.05.021).

Record type: Article


Asthma is a heterogeneous disorder hallmarked by chronic inflammation in the respiratory system. Exacerbations of asthma are correlated with respiratory infections. Considering the implication of interferon regulatory factor 5 (IRF5) in innate and adaptive immunity, we investigated the preferential transmission patterns of ten IRF5 gene polymorphisms in two asthmatic family cohorts. A common IRF5 haplotype was found to be associated with asthma and the severity of asthmatic symptoms. Stratified analysis of subgroups of asthmatic individuals revealed that the associations were more pronounced in nonatopic asthmatic individuals. In addition, the risk alleles of IRF5 polymorphisms for asthma were almost completely opposite to those for autoimmune disorders. Our study provides the first evidence of association between IRF5 and asthma, and sheds light on the related but potentially distinct roles of IRF5 alleles in the pathogenesis of asthma and autoimmune disorders.

Full text not available from this repository.

More information

Accepted/In Press date: 18 May 2012
Published date: August 2012
Organisations: Cancer Sciences, Human Development & Health, Clinical & Experimental Sciences


Local EPrints ID: 339167
ISSN: 0378-1119
PURE UUID: fe1712be-58df-49e6-82f2-830a358653e5
ORCID for John W. Holloway: ORCID iD

Catalogue record

Date deposited: 23 May 2012 16:05
Last modified: 18 Jul 2017 05:54

Export record



Author: Chuan Wang
Author: Gerard H. Koppelman
Author: Johanna K. Sandling
Author: Dirkje S. Postma
Author: Vincent Bours
Author: Ann-Christine Syvänen
Author: Vinciane Dideberg

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.