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Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma

Record type: Article

Asthma is a heterogeneous disorder hallmarked by chronic inflammation in the respiratory system. Exacerbations of asthma are correlated with respiratory infections. Considering the implication of interferon regulatory factor 5 (IRF5) in innate and adaptive immunity, we investigated the preferential transmission patterns of ten IRF5 gene polymorphisms in two asthmatic family cohorts. A common IRF5 haplotype was found to be associated with asthma and the severity of asthmatic symptoms. Stratified analysis of subgroups of asthmatic individuals revealed that the associations were more pronounced in nonatopic asthmatic individuals. In addition, the risk alleles of IRF5 polymorphisms for asthma were almost completely opposite to those for autoimmune disorders. Our study provides the first evidence of association between IRF5 and asthma, and sheds light on the related but potentially distinct roles of IRF5 alleles in the pathogenesis of asthma and autoimmune disorders.

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Citation

Wang, Chuan, Rose-Zerilli, Matthew J., Koppelman, Gerard H., Sandling, Johanna K., Holloway, John W., Postma, Dirkje S., Holgate, Stephen T., Bours, Vincent, Syvänen, Ann-Christine and Dideberg, Vinciane (2012) Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma Gene, 504, (2), pp. 220-225. (doi:10.1016/j.gene.2012.05.021).

More information

Accepted/In Press date: 18 May 2012
Published date: August 2012
Organisations: Cancer Sciences, Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 339167
URI: http://eprints.soton.ac.uk/id/eprint/339167
ISSN: 0378-1119
PURE UUID: fe1712be-58df-49e6-82f2-830a358653e5
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 23 May 2012 16:05
Last modified: 18 Jul 2017 05:54

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Contributors

Author: Chuan Wang
Author: Gerard H. Koppelman
Author: Johanna K. Sandling
Author: Dirkje S. Postma
Author: Vincent Bours
Author: Ann-Christine Syvänen
Author: Vinciane Dideberg

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