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Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction

Teeling, Jessica L., Carare, Roxana O., Glennie, Martin J. and Perry, V. Hugh (2012) Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction Acta Neuropathologica, 124, (4), pp. 479-490. (doi:10.1007/s00401-012-0995-3).

Record type: Article

Abstract

Abstract In this study, we investigate the underlying mechanisms of antibody-mediated inflammation in the brain. We show that immune complexes formed in the brain parenchyma generate a robust and long-lasting inflammatory response, characterized by increased expression of the microglia markers CD11b, CD68 and FcRII/III, but no neu- trophil recruitment. In addition to these histological changes, we observed transient behavioural changes that coincided with the inflammatory response in the brain. The inflamma- tory and behavioural changes were absent in Fc-gamma chain (Fcc)-deficient mice, while C1q-deficient mice were not dif- ferent from wild-type mice. We conclude that, in the presence of antigen, antibodies can lead to a local immune complex- mediated inflammatory reaction in the brain parenchyma and indirectly induce neuronal tissue damage through recruitment and activation of microglia via Fcc receptors. These obser- vations may have important implications for the development of therapeutic antibodies directed against neuronal antigens used for therapeutic intervention in neurological diseases.

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Published date: 23 May 2012
Organisations: Faculty of Natural and Environmental Sciences, Faculty of Medicine, Cancer Sciences, Centre for Biological Sciences

Identifiers

Local EPrints ID: 339169
URI: http://eprints.soton.ac.uk/id/eprint/339169
ISSN: 0001-6322
PURE UUID: 05a01c7f-7cbb-4a9b-b9c6-505708b996c3

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Date deposited: 24 May 2012 12:50
Last modified: 18 Jul 2017 05:54

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