The University of Southampton
University of Southampton Institutional Repository

Predicting fatigue in patients using home parenteral nutrition: a longitudinal study

Huisman-de Waal, Getty, Bazelmans, Ellen, van Achterberg, Theo, Jansen, Jan, Sauerwein, Hans, Wanten, Geert and Schoonhoven, Lisette (2011) Predicting fatigue in patients using home parenteral nutrition: a longitudinal study International Journal of Behavioral Medicine, 18, (3), pp. 268-276. (doi:10.1007/s12529-010-9116-7). (PMID:20862618).

Record type: Article


Background: Home parenteral nutrition (HPN) is a lifesaving therapy for patients with diseases that preclude adequate oral or enteral food intake. HPN has a large impact on daily life. Many patients suffer from fatigue and depression, and they experience limits in social activities. This all contributes to a lower quality of life.

Purpose: Fatigue is the most frequently mentioned problem in Dutch HPN patients. Therefore, we studied the prevalence, course and predictors of fatigue in these patients.

Methods: Patients completed questionnaires at baseline and follow-up (12 months later). Measurements included fatigue, depression, functional impairment, social support, self-efficacy, coping, anxiety and acceptance. Laboratory measures, including total bilirubin, creatinine, albumin and haemoglobin levels, were obtained from the medical records. Descriptive statistics, correlations and linear regression analysis were performed.

Results: The response rate was 71% (n=75). Sixty-five per cent of the patients were severely fatigued (n=49). Eighty-nine per cent experienced persistent fatigue. Baseline fatigue predicted 57% of the variance of fatigue at follow-up, and avoidance was responsible for 3% of the variance. No significant correlations between fatigue and laboratory measures were found. A cross-sectional analysis showed
that 46% of the variance of fatigue was explained by functional impairment, self-efficacy and depression.

Conclusion: Severe fatigue is a persistent problem for HPN
patients. Baseline fatigue was the strongest predictor of fatigue at follow-up. Functional impairment, self-efficacy and depression are strongly related to fatigue. Early recognition and treatment of fatigue are important.

PDF Huisman-de_Waal_et_al_Predicting_fatigue_home_parenteral_nurtrition.pdf - Version of Record
Restricted to Repository staff only
Download (182kB)

More information

Published date: September 2011
Keywords: home parenteral nutrition, fatigue, functional impairment, self-efficacy, depression
Organisations: Faculty of Health Sciences


Local EPrints ID: 339201
ISSN: 1070-5503
PURE UUID: bcba741f-bea5-4852-8a5c-fa07e5007ee2
ORCID for Lisette Schoonhoven: ORCID iD

Catalogue record

Date deposited: 25 May 2012 09:02
Last modified: 18 Jul 2017 05:53

Export record



Author: Getty Huisman-de Waal
Author: Ellen Bazelmans
Author: Theo van Achterberg
Author: Jan Jansen
Author: Hans Sauerwein
Author: Geert Wanten

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.