Triggering of TNFRSF25 promotes CD8+ T-cell responses and anti-tumor immunity

Slebioda, Tomasz J., Rowley, Tania F., Ferdinand, John R., Willoughby, Jane E., Buchan, Sarah L., Taraban, Vadim Y. and Al-Shamkhani, Aymen (2011) Triggering of TNFRSF25 promotes CD8+ T-cell responses and anti-tumor immunity European Journal of Immunology, 41, (9), pp. 2606-2611. (doi:10.1002/eji.201141477). (PMID:21688261).


Full text not available from this repository.


TNFRSF25 is a member of the TNF receptor superfamily (TNFRSF) that binds to the TNF-like protein TL1A. Although recent studies have demonstrated a role for TNFRSF25 in regulating CD4+ T-cell responses, it remains to be determined if TNFRSF25 functions as a costimulatory receptor for CD8+ T cells. Here, we demonstrate that ectopic expression of TL1A on mouse plasmacytomas promotes elimination of tumor cells in a CD8+ T-cell-dependent manner and renders mice immune to a subsequent challenge with tumor cells. To gain further insight into the role of TNFRSF25 in CD8+ T-cell responses, we analyzed the effect of TNFRSF25 triggering on OT-I TCR transgenic T cells. We demonstrate that TNFRSF25 triggering in vivo with soluble TL1A promotes the proliferation and accumulation of antigen-specific CD8+ T cells as well as their differentiation into CTLs. Furthermore, we show that TNFRSF25 also functions as a costimulatory receptor for memory CD8+ T cells. Thus, TNFRSF25 triggering enhances the secondary expansion of endogenous antigen-specific memory CD8+ T cells. Our data suggest that TNFRSF25 agonists, such as soluble TL1A, could potentially be used to enhance the immunogenicity of vaccines that aim to elicit human anti-tumor CD8+ T cells.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/eji.201141477
ISSNs: 0014-2980 (print)
Keywords: costimulation, CTL, death receptor 3
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Organisations: Cancer Sciences, Human Development & Health
ePrint ID: 339277
Date :
Date Event
September 2011Published
Date Deposited: 25 May 2012 12:28
Last Modified: 17 Apr 2017 17:04
Further Information:Google Scholar

Actions (login required)

View Item View Item