The University of Southampton
University of Southampton Institutional Repository

Triggering of TNFRSF25 promotes CD8+ T-cell responses and anti-tumor immunity

Slebioda, Tomasz J., Rowley, Tania F., Ferdinand, John R., Willoughby, Jane E., Buchan, Sarah L., Taraban, Vadim Y. and Al-Shamkhani, Aymen (2011) Triggering of TNFRSF25 promotes CD8+ T-cell responses and anti-tumor immunity European Journal of Immunology, 41, (9), pp. 2606-2611. (doi:10.1002/eji.201141477). (PMID:21688261).

Record type: Article


TNFRSF25 is a member of the TNF receptor superfamily (TNFRSF) that binds to the TNF-like protein TL1A. Although recent studies have demonstrated a role for TNFRSF25 in regulating CD4+ T-cell responses, it remains to be determined if TNFRSF25 functions as a costimulatory receptor for CD8+ T cells. Here, we demonstrate that ectopic expression of TL1A on mouse plasmacytomas promotes elimination of tumor cells in a CD8+ T-cell-dependent manner and renders mice immune to a subsequent challenge with tumor cells. To gain further insight into the role of TNFRSF25 in CD8+ T-cell responses, we analyzed the effect of TNFRSF25 triggering on OT-I TCR transgenic T cells. We demonstrate that TNFRSF25 triggering in vivo with soluble TL1A promotes the proliferation and accumulation of antigen-specific CD8+ T cells as well as their differentiation into CTLs. Furthermore, we show that TNFRSF25 also functions as a costimulatory receptor for memory CD8+ T cells. Thus, TNFRSF25 triggering enhances the secondary expansion of endogenous antigen-specific memory CD8+ T cells. Our data suggest that TNFRSF25 agonists, such as soluble TL1A, could potentially be used to enhance the immunogenicity of vaccines that aim to elicit human anti-tumor CD8+ T cells.

Full text not available from this repository.

More information

Published date: September 2011
Keywords: costimulation, CTL, death receptor 3
Organisations: Cancer Sciences, Human Development & Health


Local EPrints ID: 339277
ISSN: 0014-2980
PURE UUID: d4e43e20-a7d3-4947-8eb8-3759e4dc5f56

Catalogue record

Date deposited: 25 May 2012 12:28
Last modified: 18 Jul 2017 05:53

Export record



Author: Tomasz J. Slebioda
Author: Tania F. Rowley
Author: John R. Ferdinand
Author: Jane E. Willoughby
Author: Sarah L. Buchan
Author: Vadim Y. Taraban

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.