The University of Southampton
University of Southampton Institutional Repository

Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells

Krysov, Sergey, Dias, S., Paterson, A., Mockridge, C. Ian, Potter, Kathleen N., Smith, Katherine C., Ashton-Key, Margaret, Stevenson, Freda K. and Packham, Graham (2012) Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells Blood, 119, (1), pp. 170-179. (doi:10.1182/blood-2011-07-370403). (PMID:22086413).

Record type: Article


Although long considered as a disease of failed apoptosis, it is now clear that chronic lymphocytic leukemia (CLL) cells undergo extensive cell division in vivo, especially in progressive disease. Signaling via the B-cell receptor is thought to activate proliferation and survival pathways in CLL cells and also has been linked to poor outcome. Here, we have analyzed the expression of the proto-oncoprotein MYC, an essential positive regulator of the cell cycle, after stimulation of surface IgM (sIgM). MYC expression was rapidly increased after sIgM stimulation in a subset of CLL samples. The ability of sIgM stimulation to increase MYC expression was correlated with sIgM-induced intracellular calcium fluxes. MYC induction was partially dependent on the MEK/ERK signaling pathway, and MYC and phosphorylated ERK1/2 were both expressed within proliferation centers in vivo. Although stimulation of sIgD also resulted in ERK1/2 phosphorylation, responses were relatively short lived compared with sIgM and were associated with significantly reduced MYC induction, suggesting that the kinetics of ERK1/2 activation is a critical determinant of MYC induction. Our results suggest that ERK1/2-dependent induction of MYC is likely to play an important role in antigen-induced CLL cell proliferation.

Full text not available from this repository.

More information

e-pub ahead of print date: 15 November 2011
Published date: 5 January 2012
Organisations: Cancer Sciences


Local EPrints ID: 339297
ISSN: 0006-4971
PURE UUID: 1eace1fe-c168-438a-8098-e07e2165245d

Catalogue record

Date deposited: 28 May 2012 14:07
Last modified: 01 Sep 2017 16:32

Export record



Author: Sergey Krysov
Author: S. Dias
Author: A. Paterson
Author: C. Ian Mockridge
Author: Katherine C. Smith
Author: Margaret Ashton-Key
Author: Graham Packham

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.