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Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL

Record type: Article

Fos-related antigen 1 (Fra-1) is a Fos family member overexpressed in several types of human cancers. Here, we report that Fra-1 is highly expressed in the muscle-invasive form of the carcinoma of the bladder (80%) and to a lesser extent in superficial bladder cancer (42%). We demonstrate that in this type of cancer Fra-1 is regulated via a C-terminal instability signal and C-terminal phosphorylation. We show that manipulation of Fra-1 expression levels in bladder cancer cell lines affects cell morphology, motility and proliferation. The gene coding for AXL tyrosine kinase is directly upregulated by Fra-1 in bladder cancer and in other cell lines. Importantly, our data demonstrate that AXL mediates the effect of Fra-1 on tumour cell motility but not on cell proliferation. We suggest that AXL may represent an attractive therapeutic target in cancers expressing high Fra-1 levels

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Citation

Sayan, A. Emre, Stanford, R., Vickery, R., Grigorenko, E., Diesch, J., Kulbichi, K., Mellon, J. K., Edwards, Richard, Pal, R., Greaves, P., Jariel-Encontre, I., Piechaczyk, M., Kriajevska, M. and Dhillon, A. S. (2012) Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL Oncogene, 31, (12), pp. 1493-1503. (doi:10.1038/onc.2011.336). (PMID:21822309).

More information

e-pub ahead of print date: 8 August 2011
Published date: 22 March 2012
Keywords: Fos-related antigen-1, cell motility, bladder cancer
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 339302
URI: http://eprints.soton.ac.uk/id/eprint/339302
ISSN: 0950-9232
PURE UUID: be7eaaac-421e-4c07-a574-15e7f0c02e0b

Catalogue record

Date deposited: 25 May 2012 13:22
Last modified: 18 Jul 2017 05:53

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Contributors

Author: A. Emre Sayan
Author: R. Stanford
Author: R. Vickery
Author: E. Grigorenko
Author: J. Diesch
Author: K. Kulbichi
Author: J. K. Mellon
Author: Richard Edwards
Author: R. Pal
Author: P. Greaves
Author: I. Jariel-Encontre
Author: M. Piechaczyk
Author: M. Kriajevska
Author: A. S. Dhillon

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