A pilot randomised controlled trial of an internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue
A pilot randomised controlled trial of an internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue
The majority of people affected by Multiple Sclerosis (PaMS) experience severe and disabling fatigue. MS Fatigue is poorly understood and most existing treatments have limited effectiveness. However, a recent randomised controlled trial (RCT) showed that cognitive-behaviour therapy with a clinical psychologist was effective in reducing MS fatigue severity and impact. The current study developed an Internet-based version of this intervention to make it available to a wider group of PaMS and conducted preliminary investigations of its efficacy, feasibility and cost-effectiveness in a pilot RCT.
The ‘MS Invigor8’ website was developed using agile design and substantial input from PaMS. The programme includes eight online tailored and interactive sessions along with homework tasks, intended to be accessed weekly. In the pilot trial, 40 patients were randomised to MS Invigor8 (n=23) or standard care (n=17). The MS Invigor8 group accessed sessions over 8-10 weeks and received up to three 30-50 minute telephone support sessions. Participants completed online questionnaires assessing fatigue, mood and quality of life at baseline and 10 weeks follow-up.
Large between group treatment effects were found for the primary outcomes of fatigue severity (d=1.19) and impact (d =1.22). The MS Invigor8 group also reported significantly greater improvements in anxiety and depression. Analysis suggested that the intervention may be cost-effective. Qualitative feedback suggested that participants considered this treatment approach acceptable and helpful. Technical website problems negatively affected some users’ experiences and need to be resolved. Given the promising results a larger RCT with longer term follow-up is warranted.
multiple sclerosis, fatigue, cognitive behavioural therapy (CBT), Internet-based, self-management
415-421
Moss-Morris, Rona
a502f58a-d319-49a6-8aea-9dde4efc871e
McCrone, Paul
ce0c78b3-8fba-43ff-b305-e331c00cb9f9
Yardley, Lucy
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van Kessel, Kirsten
a2800e79-187f-40c2-b471-7399abfb7c72
Wills, Gary
3a594558-6921-4e82-8098-38cd8d4e8aa0
Dennison, Laura K.
15c399cb-9a81-4948-8906-21944c033c20
17 April 2012
Moss-Morris, Rona
a502f58a-d319-49a6-8aea-9dde4efc871e
McCrone, Paul
ce0c78b3-8fba-43ff-b305-e331c00cb9f9
Yardley, Lucy
64be42c4-511d-484d-abaa-f8813452a22e
van Kessel, Kirsten
a2800e79-187f-40c2-b471-7399abfb7c72
Wills, Gary
3a594558-6921-4e82-8098-38cd8d4e8aa0
Dennison, Laura K.
15c399cb-9a81-4948-8906-21944c033c20
Moss-Morris, Rona, McCrone, Paul, Yardley, Lucy, van Kessel, Kirsten, Wills, Gary and Dennison, Laura K.
(2012)
A pilot randomised controlled trial of an internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue.
Behaviour Research and Therapy, 50 (6), .
(doi:10.1016/j.brat.2012.03.001).
(PMID:22516321)
Abstract
The majority of people affected by Multiple Sclerosis (PaMS) experience severe and disabling fatigue. MS Fatigue is poorly understood and most existing treatments have limited effectiveness. However, a recent randomised controlled trial (RCT) showed that cognitive-behaviour therapy with a clinical psychologist was effective in reducing MS fatigue severity and impact. The current study developed an Internet-based version of this intervention to make it available to a wider group of PaMS and conducted preliminary investigations of its efficacy, feasibility and cost-effectiveness in a pilot RCT.
The ‘MS Invigor8’ website was developed using agile design and substantial input from PaMS. The programme includes eight online tailored and interactive sessions along with homework tasks, intended to be accessed weekly. In the pilot trial, 40 patients were randomised to MS Invigor8 (n=23) or standard care (n=17). The MS Invigor8 group accessed sessions over 8-10 weeks and received up to three 30-50 minute telephone support sessions. Participants completed online questionnaires assessing fatigue, mood and quality of life at baseline and 10 weeks follow-up.
Large between group treatment effects were found for the primary outcomes of fatigue severity (d=1.19) and impact (d =1.22). The MS Invigor8 group also reported significantly greater improvements in anxiety and depression. Analysis suggested that the intervention may be cost-effective. Qualitative feedback suggested that participants considered this treatment approach acceptable and helpful. Technical website problems negatively affected some users’ experiences and need to be resolved. Given the promising results a larger RCT with longer term follow-up is warranted.
Text
MS_Invigor8_final_submitted_June_2011.pdf
- Author's Original
More information
Published date: 17 April 2012
Keywords:
multiple sclerosis, fatigue, cognitive behavioural therapy (CBT), Internet-based, self-management
Organisations:
Human Wellbeing, Electronic & Software Systems
Identifiers
Local EPrints ID: 340097
URI: http://eprints.soton.ac.uk/id/eprint/340097
ISSN: 0005-7967
PURE UUID: acd81fc4-c4c8-4118-9fcf-6bed172452e1
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Date deposited: 11 Jun 2012 12:43
Last modified: 15 Mar 2024 03:26
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Contributors
Author:
Rona Moss-Morris
Author:
Paul McCrone
Author:
Kirsten van Kessel
Author:
Gary Wills
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