VEGF is indirectly associated with NO production

Siervo, Mario, Tomatis, Virginia, Blossom, C.M. Stephen, Feelisch, Martin and Bluck, Les C.J. (2012) VEGF is indirectly associated with NO production European Journal of Clinical Investigation, 42, (9), pp. 967-973. (doi:10.1111/j.1365-2362.2012.02684.x). (PMID:22568403).


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Background? Increased levels of vascular endothelial growth factor (VEGF) have been observed in patients with metabolic syndrome (MetS). Nitric oxide (NO) formation is reduced in MetS, but its relationship to VEGF production remains poorly defined. We evaluated the association between VEGF/NO synthesis and insulin sensitivity in obese subjects and investigated the secretory response of VEGF to an acute elevation of glucose.

Materials and methods? Seven healthy normal-weight subjects, seven obese subjects without MetS and seven obese subjects with MetS were recruited. Anthropometry, body composition and cardiometabolic functions (blood pressure, glucose, insulin, triglycerides, total cholesterol, HDL-C and VEGF) were measured, and a novel stable isotope method was used to assess in vivo rates of NO production. A frequent sampling intravenous glucose tolerance test was performed to study the dynamics of VEGF release.

Results? Fasting VEGF levels were significantly higher in the two obese groups compared to the control group (P for trend = 0·02), but the difference was not significant after adjustment for age. Vascular endothelial growth factor levels were associated with systolic blood pressure (? = 0·54; P = 0·01) and NO production (? = ?0·44; P = 0·04). Vascular endothelial growth factor levels increased in response to acute hyperglycaemia in normal-weight and obese subjects (P < 0·001).

Conclusions? Vascular endothelial growth factor levels rapidly increase during hyperglycaemia and are inversely related to NO production at steady state. The potential link between the acute secretion of VEGF and atherosclerotic risk in subjects with poorly controlled glycaemia as well as the potential of lowering elevated VEGF levels by increasing NO production and/or availability warrants further investigation.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.1365-2362.2012.02684.x
ISSNs: 0014-2972 (print)
Keywords: hyperglycaemia, nitric oxide, obesity, vascular endothelial growth factor
Organisations: Clinical & Experimental Sciences
ePrint ID: 340187
Date :
Date Event
8 May 2012e-pub ahead of print
September 2012Published
Date Deposited: 14 Jun 2012 11:59
Last Modified: 17 Apr 2017 16:58
Further Information:Google Scholar

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