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Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology

Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology
Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology
Microdroplets in microfluidics offer a great number of opportunities in chemical and biological research. They provide a compartment in which species or reactions can be isolated, they are monodisperse and therefore suitable for quantitative studies, they offer the possibility to work with extremely small volumes, single cells, or single molecules, and are suitable for high-throughput experiments. The aim of this Review is to show the importance of these features in enabling new experiments in biology and chemistry. The recent advances in device fabrication are highlighted as are the remaining technological challenges. Examples are presented to show how compartmentalization, monodispersity, single-molecule sensitivity, and high throughput have been exploited in experiments that would have been extremely difficult outside the microfluidics platform.

1433-7851
5846-5868
Theberge, Ashleigh B.
2a31a70c-8a1a-432c-bcea-f4e83285e507
Courtois, Fabienne
96fbdf6b-bebc-442e-9701-f87be80c54c6
Schaerli, Yolanda
dad6dfa3-2474-49a6-a03d-c6282e857bb7
Fischlechner, Martin
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Abell, Chris
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Hollfelder, Florian
a9f01280-f05d-4057-b5d7-85eac249e477
Huck, Wilhelm T. S.
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Theberge, Ashleigh B.
2a31a70c-8a1a-432c-bcea-f4e83285e507
Courtois, Fabienne
96fbdf6b-bebc-442e-9701-f87be80c54c6
Schaerli, Yolanda
dad6dfa3-2474-49a6-a03d-c6282e857bb7
Fischlechner, Martin
b3930129-0775-4c05-81c7-475934df97ee
Abell, Chris
9b071a5d-04c5-464e-8d19-e37e41d1a046
Hollfelder, Florian
a9f01280-f05d-4057-b5d7-85eac249e477
Huck, Wilhelm T. S.
1495471b-acd7-40d2-a32e-99b98d36b936

Theberge, Ashleigh B., Courtois, Fabienne, Schaerli, Yolanda, Fischlechner, Martin, Abell, Chris, Hollfelder, Florian and Huck, Wilhelm T. S. (2010) Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. Angewandte Chemie International Edition, 49 (34), 5846-5868. (doi:10.1002/anie.200906653).

Record type: Article

Abstract

Microdroplets in microfluidics offer a great number of opportunities in chemical and biological research. They provide a compartment in which species or reactions can be isolated, they are monodisperse and therefore suitable for quantitative studies, they offer the possibility to work with extremely small volumes, single cells, or single molecules, and are suitable for high-throughput experiments. The aim of this Review is to show the importance of these features in enabling new experiments in biology and chemistry. The recent advances in device fabrication are highlighted as are the remaining technological challenges. Examples are presented to show how compartmentalization, monodispersity, single-molecule sensitivity, and high throughput have been exploited in experiments that would have been extremely difficult outside the microfluidics platform.

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Published date: 22 June 2010
Organisations: Chemistry

Identifiers

Local EPrints ID: 340192
URI: http://eprints.soton.ac.uk/id/eprint/340192
ISSN: 1433-7851
PURE UUID: 65331850-78c0-4c05-a86b-e7372f05aff2

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Date deposited: 14 Jun 2012 13:51
Last modified: 16 Dec 2019 20:38

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Contributors

Author: Ashleigh B. Theberge
Author: Fabienne Courtois
Author: Yolanda Schaerli
Author: Martin Fischlechner
Author: Chris Abell
Author: Florian Hollfelder
Author: Wilhelm T. S. Huck

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