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Frequency-specific flow control in microfluidic circuits with passive elastomeric features

Frequency-specific flow control in microfluidic circuits with passive elastomeric features
Frequency-specific flow control in microfluidic circuits with passive elastomeric features
A fundamental challenge in the design of microfluidic devices lies in the need to control the transport of fluid according to complex patterns in space and time, and with sufficient accuracy. Although strategies based on externally actuated valves have enabled marked breakthroughs in chip-based analysis1, 2, 3, 4, 5, this requires significant off-chip hardware, such as vacuum pumps and switching solenoids, which strongly tethers such devices to laboratory environments6, 7, 8, 9, 10. Severing the microfluidic chip from this off-chip hardware would enable a new generation of devices that place the power of microfluidics in a broader range of disciplines. For example, complete on-chip flow control would empower highly portable microfluidic tools for diagnostics, forensics, environmental analysis and food safety, and be particularly useful in field settings where infrastructure is limited. Here, we demonstrate an elegantly simple strategy for flow control: fluidic networks with embedded deformable features are shown to transport fluid selectively in response to the frequency of a time-modulated pressure source. Distinct fluidic flow patterns are activated through the dynamic control of a single pressure input, akin to the analog responses of passive electrical circuits composed of resistors, capacitors and diodes

1745-2473
231-235
Leslie, Daniel C.
cfba1079-7234-4c99-a459-3501f1ce5df5
Easley, Christopher J.
a2a731c7-3f06-4c57-81c5-653a1c1c268c
Seker, Erkin
2583be7e-b2c4-4947-b91e-b5ffd5d4a4df
Karlinsey, James M.
30280dcc-3031-4226-8a4f-2469309166d5
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Begley, Matthew R.
9f4e52bc-507a-4ef6-910f-bd11d25c2209
Landers, James P.
f85edaa2-5c24-4f2d-be3d-c84e631833ad
Leslie, Daniel C.
cfba1079-7234-4c99-a459-3501f1ce5df5
Easley, Christopher J.
a2a731c7-3f06-4c57-81c5-653a1c1c268c
Seker, Erkin
2583be7e-b2c4-4947-b91e-b5ffd5d4a4df
Karlinsey, James M.
30280dcc-3031-4226-8a4f-2469309166d5
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Begley, Matthew R.
9f4e52bc-507a-4ef6-910f-bd11d25c2209
Landers, James P.
f85edaa2-5c24-4f2d-be3d-c84e631833ad

Leslie, Daniel C., Easley, Christopher J., Seker, Erkin, Karlinsey, James M., Utz, Marcel, Begley, Matthew R. and Landers, James P. (2009) Frequency-specific flow control in microfluidic circuits with passive elastomeric features. Nature Physics, 5 (3), 231-235. (doi:10.1038/NPHYS1196).

Record type: Article

Abstract

A fundamental challenge in the design of microfluidic devices lies in the need to control the transport of fluid according to complex patterns in space and time, and with sufficient accuracy. Although strategies based on externally actuated valves have enabled marked breakthroughs in chip-based analysis1, 2, 3, 4, 5, this requires significant off-chip hardware, such as vacuum pumps and switching solenoids, which strongly tethers such devices to laboratory environments6, 7, 8, 9, 10. Severing the microfluidic chip from this off-chip hardware would enable a new generation of devices that place the power of microfluidics in a broader range of disciplines. For example, complete on-chip flow control would empower highly portable microfluidic tools for diagnostics, forensics, environmental analysis and food safety, and be particularly useful in field settings where infrastructure is limited. Here, we demonstrate an elegantly simple strategy for flow control: fluidic networks with embedded deformable features are shown to transport fluid selectively in response to the frequency of a time-modulated pressure source. Distinct fluidic flow patterns are activated through the dynamic control of a single pressure input, akin to the analog responses of passive electrical circuits composed of resistors, capacitors and diodes

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e-pub ahead of print date: 1 February 2009
Published date: March 2009
Organisations: Chemistry

Identifiers

Local EPrints ID: 340206
URI: http://eprints.soton.ac.uk/id/eprint/340206
ISSN: 1745-2473
PURE UUID: b9d77cad-b588-47f6-b2b8-d691aab8bd4b
ORCID for Marcel Utz: ORCID iD orcid.org/0000-0003-2274-9672

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Date deposited: 15 Jun 2012 08:29
Last modified: 19 Nov 2019 01:37

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Contributors

Author: Daniel C. Leslie
Author: Christopher J. Easley
Author: Erkin Seker
Author: James M. Karlinsey
Author: Marcel Utz ORCID iD
Author: Matthew R. Begley
Author: James P. Landers

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