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Improving mechanical properties of crystalline solids by cocrystal formation: new compressible forms of paracetamol

Improving mechanical properties of crystalline solids by cocrystal formation: new compressible forms of paracetamol
Improving mechanical properties of crystalline solids by cocrystal formation: new compressible forms of paracetamol
Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.
1521-4095
3905-3909
Karki, Shyam
2a2e5b32-f2a8-4b2e-b9a9-0f298f02a6a1
Friščić, Tomislav
26e7e7b1-fc27-4731-827b-f09eadc14d14
Fábián, László
3bcf43d0-8aef-49d4-a4d2-e10162f8ac6d
Laity, Peter R.
ba8a7df6-0703-4154-939f-9de18080bc52
Day, Graeme M.
e3be79ba-ad12-4461-b735-74d5c4355636
Jones, William
3173abf0-1cfa-45f0-996e-2586b385c21e
Karki, Shyam
2a2e5b32-f2a8-4b2e-b9a9-0f298f02a6a1
Friščić, Tomislav
26e7e7b1-fc27-4731-827b-f09eadc14d14
Fábián, László
3bcf43d0-8aef-49d4-a4d2-e10162f8ac6d
Laity, Peter R.
ba8a7df6-0703-4154-939f-9de18080bc52
Day, Graeme M.
e3be79ba-ad12-4461-b735-74d5c4355636
Jones, William
3173abf0-1cfa-45f0-996e-2586b385c21e

Karki, Shyam, Friščić, Tomislav, Fábián, László, Laity, Peter R., Day, Graeme M. and Jones, William (2009) Improving mechanical properties of crystalline solids by cocrystal formation: new compressible forms of paracetamol. Advanced Materials, 21 (38-39), 3905-3909. (doi:10.1002/adma.200900533).

Record type: Article

Abstract

Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

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More information

Published date: 19 October 2009
Organisations: Chemistry

Identifiers

Local EPrints ID: 340210
URI: http://eprints.soton.ac.uk/id/eprint/340210
ISSN: 1521-4095
PURE UUID: 10c66a96-b465-42cf-8341-50b14d3cfd64
ORCID for Graeme M. Day: ORCID iD orcid.org/0000-0001-8396-2771

Catalogue record

Date deposited: 15 Jun 2012 09:06
Last modified: 17 Dec 2019 01:38

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