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An adaptable peptide-based porous material

An adaptable peptide-based porous material
An adaptable peptide-based porous material
Porous materials find widespread application in storage, separation, and catalytic technologies. We report a crystalline porous solid with adaptable porosity, in which a simple dipeptide linker is arranged in a regular array by coordination to metal centers. Experiments reinforced by molecular dynamics simulations showed that low-energy torsions and displacements of the peptides enabled the available pore volume to evolve smoothly from zero as the guest loading increased. The observed cooperative feedback in sorption isotherms resembled the response of proteins undergoing conformational selection, suggesting an energy landscape similar to that required for protein folding. The flexible peptide linker was shown to play the pivotal role in changing the pore conformation.
0036-8075
1053-1057
Rabone, J.
928a4f79-be13-4fc4-8ca8-ae74a7c45a9b
Yue, Y.-F.
a00f08f8-5e36-4a38-a698-ee16cfa24e6e
Chong, S.Y.
5db9c25a-7422-4cf9-acd7-d54d4ab5c6b6
Stylianou, K.C.
667f4c6f-3328-4ac7-9d04-a03e61255ddb
Bacsa, J.
9d918894-f10c-4d6c-8015-b10cf81dab4b
Bradshaw, D.
7677b11e-1961-447e-b9ba-4847a74bd4dd
Darling, G.R.
6c01022b-f1cf-4a85-804a-ae8b161efc4b
Berry, N.G.
4c3e79a4-fcea-4d78-ab27-9bd19e845da0
Khimyak, Y.Z.
2941ca32-bdd9-4996-842c-3275b6df63ec
Ganin, A.Y.
7a85a693-9b45-43bb-bf8b-d737b4d9ac37
Wiper, P.
8b853209-fe6e-4306-a055-399a709ec4c1
Claridge, J.B.
a4f4260f-00bf-44b5-bb01-4545c189ff65
Rosseinsky, M.J.
808fd50e-8b5c-4bd5-8cc3-a4ddd27a9fe6
Rabone, J.
928a4f79-be13-4fc4-8ca8-ae74a7c45a9b
Yue, Y.-F.
a00f08f8-5e36-4a38-a698-ee16cfa24e6e
Chong, S.Y.
5db9c25a-7422-4cf9-acd7-d54d4ab5c6b6
Stylianou, K.C.
667f4c6f-3328-4ac7-9d04-a03e61255ddb
Bacsa, J.
9d918894-f10c-4d6c-8015-b10cf81dab4b
Bradshaw, D.
7677b11e-1961-447e-b9ba-4847a74bd4dd
Darling, G.R.
6c01022b-f1cf-4a85-804a-ae8b161efc4b
Berry, N.G.
4c3e79a4-fcea-4d78-ab27-9bd19e845da0
Khimyak, Y.Z.
2941ca32-bdd9-4996-842c-3275b6df63ec
Ganin, A.Y.
7a85a693-9b45-43bb-bf8b-d737b4d9ac37
Wiper, P.
8b853209-fe6e-4306-a055-399a709ec4c1
Claridge, J.B.
a4f4260f-00bf-44b5-bb01-4545c189ff65
Rosseinsky, M.J.
808fd50e-8b5c-4bd5-8cc3-a4ddd27a9fe6

Rabone, J., Yue, Y.-F., Chong, S.Y., Stylianou, K.C., Bacsa, J., Bradshaw, D., Darling, G.R., Berry, N.G., Khimyak, Y.Z., Ganin, A.Y., Wiper, P., Claridge, J.B. and Rosseinsky, M.J. (2010) An adaptable peptide-based porous material. Science, 329 (5995), 1053-1057. (doi:10.1126/science.1190672). (PMID:20798314)

Record type: Article

Abstract

Porous materials find widespread application in storage, separation, and catalytic technologies. We report a crystalline porous solid with adaptable porosity, in which a simple dipeptide linker is arranged in a regular array by coordination to metal centers. Experiments reinforced by molecular dynamics simulations showed that low-energy torsions and displacements of the peptides enabled the available pore volume to evolve smoothly from zero as the guest loading increased. The observed cooperative feedback in sorption isotherms resembled the response of proteins undergoing conformational selection, suggesting an energy landscape similar to that required for protein folding. The flexible peptide linker was shown to play the pivotal role in changing the pore conformation.

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Published date: 27 August 2010
Organisations: Chemistry

Identifiers

Local EPrints ID: 340213
URI: http://eprints.soton.ac.uk/id/eprint/340213
ISSN: 0036-8075
PURE UUID: f44127f6-07b2-4aa0-b83a-d421534230ae
ORCID for D. Bradshaw: ORCID iD orcid.org/0000-0001-5258-6224

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Date deposited: 15 Jun 2012 11:08
Last modified: 17 Dec 2019 01:39

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Contributors

Author: J. Rabone
Author: Y.-F. Yue
Author: S.Y. Chong
Author: K.C. Stylianou
Author: J. Bacsa
Author: D. Bradshaw ORCID iD
Author: G.R. Darling
Author: N.G. Berry
Author: Y.Z. Khimyak
Author: A.Y. Ganin
Author: P. Wiper
Author: J.B. Claridge
Author: M.J. Rosseinsky

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