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Formal highly enantioselective organocatalytic addition of fluoromethyl anion to ?,?-unsaturated aldehydes

Formal highly enantioselective organocatalytic addition of fluoromethyl anion to ?,?-unsaturated aldehydes
Formal highly enantioselective organocatalytic addition of fluoromethyl anion to ?,?-unsaturated aldehydes
Symmetric fluoromethylation made easy: a highly enantioselective fluoromethyl addition to ?,?-unsaturated aldehydes is described (see scheme). The synthesis of chiral fluorinated blocks, including ?-fluoro-?-aminoalcohol derivatives is disclosed.
enantioselectivity, fluorine, organocatalysis, nucleophilic addition, stereoselectivity
0947-6539
7035-7038
Alba, Andrea-Nekane
e96df5c1-b984-45c5-9620-1d7f0cec8faf
Companyó, Xavier
446791db-6e0a-40f9-9f20-3a8e8af9803c
Moyano, Albert
07f92405-40f4-4fc4-97b3-9bd5c9c14baa
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Alba, Andrea-Nekane
e96df5c1-b984-45c5-9620-1d7f0cec8faf
Companyó, Xavier
446791db-6e0a-40f9-9f20-3a8e8af9803c
Moyano, Albert
07f92405-40f4-4fc4-97b3-9bd5c9c14baa
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441

Alba, Andrea-Nekane, Companyó, Xavier, Moyano, Albert and Rios, Ramon (2009) Formal highly enantioselective organocatalytic addition of fluoromethyl anion to ?,?-unsaturated aldehydes. Chemistry - A European Journal, 15 (29), 7035-7038. (doi:10.1002/chem.200900991). (PMID:19551792)

Record type: Article

Abstract

Symmetric fluoromethylation made easy: a highly enantioselective fluoromethyl addition to ?,?-unsaturated aldehydes is described (see scheme). The synthesis of chiral fluorinated blocks, including ?-fluoro-?-aminoalcohol derivatives is disclosed.

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More information

e-pub ahead of print date: 23 June 2009
Published date: 20 July 2009
Keywords: enantioselectivity, fluorine, organocatalysis, nucleophilic addition, stereoselectivity
Organisations: Chemistry
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Identifiers

Local EPrints ID: 340220
URI: http://eprints.soton.ac.uk/id/eprint/340220
DOI: doi:10.1002/chem.200900991
ISSN: 0947-6539
PURE UUID: d7c1a5f2-9213-4f16-b829-daeb2d4c4d50
ORCID for Ramon Rios: ORCID iD orcid.org/0000-0002-3843-8521

Catalogue record

Date deposited: 15 Jun 2012 12:21
Last modified: 14 Mar 2024 11:20

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Contributors

Author: Andrea-Nekane Alba
Author: Xavier Companyó
Author: Albert Moyano
Author: Ramon Rios ORCID iD

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