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Risk of cataract and glaucoma in patients with multiple sclerosis

Risk of cataract and glaucoma in patients with multiple sclerosis
Risk of cataract and glaucoma in patients with multiple sclerosis
Background: the aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.

Methods: we conducted a population-based cohort study utilizing the UK General Practice Research Database (1987–2009) linked to the national hospital registry of England (1997–2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.

Results: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94–1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78–1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56–3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01–2.86)) was significantly greater in patients < 50 years, particularly in men < 50 years: cataract, adj. HR 4.23 (95% CI 2.22–8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28–5.93).

Conclusion: this is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men
1352-4585
628-638
Bazelier, Marloes T.
701385a8-2cb1-4258-88a4-249c3a7f07f5
Mueller-Schotte, Sigrid
c4675bab-7b21-44ca-b367-46274e8b405d
Leufkens, Hubert G.M.
299d1b54-3a02-48a9-9ffb-71ba2c3fa469
Uitdehaag, Bernard M.J.
67942e99-5537-4583-83d9-2d731f7199e0
van Staa, Tjeerd
76db275d-12ed-44e8-8dd1-2d70e945fc07
de Vries, Frank
10245a32-6083-4feb-9d20-7e7db0f358b1
Bazelier, Marloes T.
701385a8-2cb1-4258-88a4-249c3a7f07f5
Mueller-Schotte, Sigrid
c4675bab-7b21-44ca-b367-46274e8b405d
Leufkens, Hubert G.M.
299d1b54-3a02-48a9-9ffb-71ba2c3fa469
Uitdehaag, Bernard M.J.
67942e99-5537-4583-83d9-2d731f7199e0
van Staa, Tjeerd
76db275d-12ed-44e8-8dd1-2d70e945fc07
de Vries, Frank
10245a32-6083-4feb-9d20-7e7db0f358b1

Bazelier, Marloes T., Mueller-Schotte, Sigrid, Leufkens, Hubert G.M., Uitdehaag, Bernard M.J., van Staa, Tjeerd and de Vries, Frank (2012) Risk of cataract and glaucoma in patients with multiple sclerosis. Multiple Sclerosis Journal, 18 (5), 628-638. (doi:10.1177/1352458511426737). (PMID:22025330)

Record type: Article

Abstract

Background: the aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.

Methods: we conducted a population-based cohort study utilizing the UK General Practice Research Database (1987–2009) linked to the national hospital registry of England (1997–2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.

Results: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94–1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78–1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56–3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01–2.86)) was significantly greater in patients < 50 years, particularly in men < 50 years: cataract, adj. HR 4.23 (95% CI 2.22–8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28–5.93).

Conclusion: this is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men

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More information

e-pub ahead of print date: October 2011
Published date: May 2012
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 340364
URI: https://eprints.soton.ac.uk/id/eprint/340364
ISSN: 1352-4585
PURE UUID: a769b9f9-d687-489f-8365-e64984e13b32

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Date deposited: 21 Jun 2012 12:46
Last modified: 16 Jul 2019 22:00

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Contributors

Author: Marloes T. Bazelier
Author: Sigrid Mueller-Schotte
Author: Hubert G.M. Leufkens
Author: Bernard M.J. Uitdehaag
Author: Tjeerd van Staa
Author: Frank de Vries

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