The University of Southampton
University of Southampton Institutional Repository

Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers

Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers
Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers
Background: patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis.

Objective: to estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls.

Methods: the case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949–2007). Data were linked to the National Hospital Discharge Register (1977–2007). Patients with MS (n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls.

Results: among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33–1.46). In particular, IRRs of tibia fracture (3.36 [2.75–4.11]), femur fracture (6.66 [5.06–8.76]) and hip fracture (3.20 [2.83–3.62]) were elevated in MS patients versus controls.

Conclusion: fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur
1352-4585
622-627
Bazelier, Marloes T.
701385a8-2cb1-4258-88a4-249c3a7f07f5
de Vries, Frank
10245a32-6083-4feb-9d20-7e7db0f358b1
Bentzen, Joan
a383095f-902b-4a02-af2a-71d20daaeae2
Vestergaard, Peter
3336d4f1-072c-4b02-935e-a5eca05858e2
Leufkens, Hubert G.M.
299d1b54-3a02-48a9-9ffb-71ba2c3fa469
Van Staa, Tjeerd-Pieter
f840d545-0e8d-40fe-9124-976826190cc3
Koch-Henriksen, Nils
0ebeb618-f132-4433-baaa-e0dfd6184e89
Bazelier, Marloes T.
701385a8-2cb1-4258-88a4-249c3a7f07f5
de Vries, Frank
10245a32-6083-4feb-9d20-7e7db0f358b1
Bentzen, Joan
a383095f-902b-4a02-af2a-71d20daaeae2
Vestergaard, Peter
3336d4f1-072c-4b02-935e-a5eca05858e2
Leufkens, Hubert G.M.
299d1b54-3a02-48a9-9ffb-71ba2c3fa469
Van Staa, Tjeerd-Pieter
f840d545-0e8d-40fe-9124-976826190cc3
Koch-Henriksen, Nils
0ebeb618-f132-4433-baaa-e0dfd6184e89

Bazelier, Marloes T., de Vries, Frank, Bentzen, Joan, Vestergaard, Peter, Leufkens, Hubert G.M., Van Staa, Tjeerd-Pieter and Koch-Henriksen, Nils (2012) Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers. Multiple Sclerosis Journal, 18 (5), 622-627. (doi:10.1177/1352458511426739). (PMID:22020418)

Record type: Article

Abstract

Background: patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis.

Objective: to estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls.

Methods: the case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949–2007). Data were linked to the National Hospital Discharge Register (1977–2007). Patients with MS (n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls.

Results: among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33–1.46). In particular, IRRs of tibia fracture (3.36 [2.75–4.11]), femur fracture (6.66 [5.06–8.76]) and hip fracture (3.20 [2.83–3.62]) were elevated in MS patients versus controls.

Conclusion: fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur

Full text not available from this repository.

More information

e-pub ahead of print date: October 2011
Published date: May 2012
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 340426
URI: https://eprints.soton.ac.uk/id/eprint/340426
ISSN: 1352-4585
PURE UUID: 99455180-8e95-4915-812c-2443e5c90069

Catalogue record

Date deposited: 21 Jun 2012 13:18
Last modified: 16 Jul 2019 21:59

Export record

Altmetrics

Contributors

Author: Marloes T. Bazelier
Author: Frank de Vries
Author: Joan Bentzen
Author: Peter Vestergaard
Author: Hubert G.M. Leufkens
Author: Tjeerd-Pieter Van Staa
Author: Nils Koch-Henriksen

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×