The lifetime risk of total hip and knee arthroplasty: results from the UK general practice research database

Culliford, D. J., Maskell, J., Kiran, A., Judge, A., Javaid, M. K., Cooper, C. and Arden, N. K. (2012) The lifetime risk of total hip and knee arthroplasty: results from the UK general practice research database Osteoarthritis and Cartilage, 20, (6), pp. 519-524. (doi:10.1016/j.joca.2012.02.636). (PMID:22395038).


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Objective: To estimate the lifetime risk of undergoing primary total hip (THR) or knee (TKR) replacement in the UK.

Method: A Population-based cohort study of 25,845 patients who had undergone a THR and 23,260 patients who had undergone a TKR between 1991 and 2006, using data from the UK General Practice Research Database.

Results: The estimated mortality-adjusted lifetime risk of THR at age 50 for the year 2005 was 11.6% (95% CI: 11.1, 12.1) for women and 7.1% (95% CI: 6.7, 7.5) for men. For TKR the risks were 10.8% (95% CI:10.3, 11.3) for women and 8.1% (95% CI: 7.6, 8.5) for men. Between 1991 and 2006, the lifetime risk of THR at age 50 rose from 4.0% (95% CI: 3.5, 4.4) to 11.1% (95% CI: 10.6, 11.6) for women and for men from 2.2%(95% CI: 1.8, 2.5) to 6.6% (95% CI: 6.2, 7.0). Over the same period, for TKR the risk for women increased
from 2.9% (95% CI: 2.6, 3.3) to 10.6% (95% CI: 10.1, 11.1) and for men from 1.8% (95% CI: 1.5, 2.2) to 7.7%(95% CI: 7.3, 8.2).

Conclusion: The lifetime risk of undergoing THR or TKR is estimated to be substantially less than the risk of developing symptomatic hip or knee osteoarthritis. For the knee, the difference between these risk estimates is particularly wide. The reasons for the size of these differences are not clear, and further work is needed to quantify the extent of latent demand for these cost-effective and established interventions among the population with symptomatic osteoarthritis of the hip or knee.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.joca.2012.02.636
ISSNs: 1063-4584 (print)
Related URLs:
Organisations: Faculty of Health Sciences, Primary Care & Population Sciences
ePrint ID: 340439
Date :
Date Event
June 2012Published
Date Deposited: 21 Jun 2012 14:48
Last Modified: 17 Apr 2017 16:55
Further Information:Google Scholar

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