Prenatal factors contribute to the emergence of kwoshiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model
Prenatal factors contribute to the emergence of kwoshiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model
Severe acute malnutrition in childhood manifests as oedematous (kwashiorkor, marasmic kwashiorkor) and non-oedematous (marasmus) syndromes with very different prognoses. Kwashiorkor differs from marasmus in the patterns of protein, amino acid and lipid metabolism when patients are acutely ill as well as after rehabilitation to ideal weight for height. Metabolic patterns among marasmic patients define them as metabolically thrifty, while kwashiorkor patients function as metabolically profligate. Such differences might underlie syndromic presentation and prognosis. However, no fundamental explanation exists for these differences in metabolism, nor clinical pictures, given similar exposures to undernutrition. We hypothesized that different developmental trajectories underlie these clinical-metabolic phenotypes: if so this would be strong evidence in support of predictive adaptation model of developmental plasticity.
e35907-[4pp]
Forrester, Terrence E.
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Badaloo, Asha V.
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Boyne, Michael S.
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Osmond, Clive
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Thompson, Debbie
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Green, Curtis
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Taylor-Bryan, Carolyn
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Barnett, Alan
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Soares-Wynter, Suzanne
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Hanson, Mark A.
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Beedle, Alan S.
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Gluckman, Peter D.
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30 April 2012
Forrester, Terrence E.
d5ed0294-0713-4521-baf9-923f1cae5e7f
Badaloo, Asha V.
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Boyne, Michael S.
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Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Thompson, Debbie
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Green, Curtis
dec86c57-09d1-4741-b999-dc6a98a15806
Taylor-Bryan, Carolyn
a79552ce-930b-470c-b253-8cc152b30987
Barnett, Alan
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Soares-Wynter, Suzanne
6647b74b-b855-4f4e-b2d2-f553078ac5ca
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Beedle, Alan S.
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Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Forrester, Terrence E., Badaloo, Asha V., Boyne, Michael S., Osmond, Clive, Thompson, Debbie, Green, Curtis, Taylor-Bryan, Carolyn, Barnett, Alan, Soares-Wynter, Suzanne, Hanson, Mark A., Beedle, Alan S. and Gluckman, Peter D.
(2012)
Prenatal factors contribute to the emergence of kwoshiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model.
PLoS ONE, 7 (4), .
(doi:10.1371/journal.pone.0035907).
(PMID:22558267)
Abstract
Severe acute malnutrition in childhood manifests as oedematous (kwashiorkor, marasmic kwashiorkor) and non-oedematous (marasmus) syndromes with very different prognoses. Kwashiorkor differs from marasmus in the patterns of protein, amino acid and lipid metabolism when patients are acutely ill as well as after rehabilitation to ideal weight for height. Metabolic patterns among marasmic patients define them as metabolically thrifty, while kwashiorkor patients function as metabolically profligate. Such differences might underlie syndromic presentation and prognosis. However, no fundamental explanation exists for these differences in metabolism, nor clinical pictures, given similar exposures to undernutrition. We hypothesized that different developmental trajectories underlie these clinical-metabolic phenotypes: if so this would be strong evidence in support of predictive adaptation model of developmental plasticity.
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Published date: 30 April 2012
Organisations:
Faculty of Health Sciences
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Local EPrints ID: 340463
URI: http://eprints.soton.ac.uk/id/eprint/340463
ISSN: 1932-6203
PURE UUID: 8542bced-d0ba-4b85-a9cf-64e32b870915
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Date deposited: 22 Jun 2012 09:22
Last modified: 15 Mar 2024 03:07
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Contributors
Author:
Terrence E. Forrester
Author:
Asha V. Badaloo
Author:
Michael S. Boyne
Author:
Debbie Thompson
Author:
Curtis Green
Author:
Carolyn Taylor-Bryan
Author:
Alan Barnett
Author:
Suzanne Soares-Wynter
Author:
Alan S. Beedle
Author:
Peter D. Gluckman
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