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Prenatal factors contribute to the emergenece of kwoshiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model

Forrester, Terrence E., Badaloo, Asha V., Boyne, Michael S., Osmond, Clive, Thompson, Debbie, Green, Curtis, Taylor-Bryan, Carolyn, Barnett, Alan, Soares-Wynter, Suzanne, Hanson, Mark A., Beedle, Alan S. and Gluckman, Peter D. (2012) Prenatal factors contribute to the emergenece of kwoshiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model PLoS ONE, 7, (4), e35907-[4pp]. (doi:10.1371/journal.pone.0035907). (PMID:22558267).

Record type: Article


Severe acute malnutrition in childhood manifests as oedematous (kwashiorkor, marasmic kwashiorkor) and non-oedematous (marasmus) syndromes with very different prognoses. Kwashiorkor differs from marasmus in the patterns of protein, amino acid and lipid metabolism when patients are acutely ill as well as after rehabilitation to ideal weight for height. Metabolic patterns among marasmic patients define them as metabolically thrifty, while kwashiorkor patients function as metabolically profligate. Such differences might underlie syndromic presentation and prognosis. However, no fundamental explanation exists for these differences in metabolism, nor clinical pictures, given similar exposures to undernutrition. We hypothesized that different developmental trajectories underlie these clinical-metabolic phenotypes: if so this would be strong evidence in support of predictive adaptation model of developmental plasticity.

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Published date: 30 April 2012
Organisations: Faculty of Health Sciences


Local EPrints ID: 340463
ISSN: 1932-6203
PURE UUID: 8542bced-d0ba-4b85-a9cf-64e32b870915
ORCID for Clive Osmond: ORCID iD

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Date deposited: 22 Jun 2012 09:22
Last modified: 18 Jul 2017 05:44

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Author: Terrence E. Forrester
Author: Asha V. Badaloo
Author: Michael S. Boyne
Author: Clive Osmond ORCID iD
Author: Debbie Thompson
Author: Curtis Green
Author: Carolyn Taylor-Bryan
Author: Alan Barnett
Author: Suzanne Soares-Wynter
Author: Mark A. Hanson
Author: Alan S. Beedle
Author: Peter D. Gluckman

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