The University of Southampton
University of Southampton Institutional Repository

CD70-CD27 interaction augments CD8+ T-Cell activation by human epidermal langerhans cells

Polak, Marta E., Newell, Louise, Taraban, Vadim Y., Pickard, Christopher, Healy, Eugene, Friedmann, Peter S., Al-Shamkhani, Aymen and Ardern-Jones, Michael R. (2012) CD70-CD27 interaction augments CD8+ T-Cell activation by human epidermal langerhans cells Journal of Investigative Dermatology, 132, (6), pp. 1636-1644. (doi:10.1038/jid.2012.26). (PMID:22377764).

Record type: Article


Human cutaneous dendritic cells (DCs) from epidermal and dermal compartments exhibit functional differences in their induction of CD4+ T-cell and humoral immune responses; however, differences in the regulation of memory CD8+ T-cell responses by human skin DCs remain poorly characterized. We tested the capacity of human Langerhans cells (LCs) and dermal dendritic cells (DDCs) to induce antigen-specific cytokine production and proliferation of memory CD8+ cells. Although tumor necrosis factor-?-matured human DCs from both epidermal and dermal compartments showed efficient potential to activate CD8+ cells, LCs were constitutively more efficient than DDCs in cross-presenting CD8+ epitopes, as well as direct presentation of viral antigen to Epstein-Barr virus-specific CD8+ T cells. LCs showed greater expression of CD70, and blockade of CD70-CD27 signaling demonstrated that superiority of CD8+ activation by epidermal LC is CD70 dependent. This CD70-related activation of CD8+ cells by LCs denotes a central role of LCs in CD8+ immunity in skin, and suggests that regulation of LC CD70 expression is important in enhancing immunity against cutaneous epithelial pathogens and cancer.

Full text not available from this repository.

More information

e-pub ahead of print date: 1 March 2012
Published date: June 2012
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 340539
ISSN: 0022-202X
PURE UUID: 935dc765-575e-4c7a-988e-7b8897d9aa12

Catalogue record

Date deposited: 25 Jun 2012 13:11
Last modified: 18 Jul 2017 05:43

Export record



Author: Marta E. Polak
Author: Louise Newell
Author: Vadim Y. Taraban
Author: Christopher Pickard
Author: Eugene Healy
Author: Peter S. Friedmann

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.