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CD70-CD27 interaction augments CD8+ T-Cell activation by human epidermal langerhans cells

Polak, Marta E., Newell, Louise, Taraban, Vadim Y., Pickard, Christopher, Healy, Eugene, Friedmann, Peter S., Al-Shamkhani, Aymen and Ardern-Jones, Michael R. (2012) CD70-CD27 interaction augments CD8+ T-Cell activation by human epidermal langerhans cells Journal of Investigative Dermatology, 132, (6), pp. 1636-1644. (doi:10.1038/jid.2012.26). (PMID:22377764).

Record type: Article

Abstract

Human cutaneous dendritic cells (DCs) from epidermal and dermal compartments exhibit functional differences in their induction of CD4+ T-cell and humoral immune responses; however, differences in the regulation of memory CD8+ T-cell responses by human skin DCs remain poorly characterized. We tested the capacity of human Langerhans cells (LCs) and dermal dendritic cells (DDCs) to induce antigen-specific cytokine production and proliferation of memory CD8+ cells. Although tumor necrosis factor-?-matured human DCs from both epidermal and dermal compartments showed efficient potential to activate CD8+ cells, LCs were constitutively more efficient than DDCs in cross-presenting CD8+ epitopes, as well as direct presentation of viral antigen to Epstein-Barr virus-specific CD8+ T cells. LCs showed greater expression of CD70, and blockade of CD70-CD27 signaling demonstrated that superiority of CD8+ activation by epidermal LC is CD70 dependent. This CD70-related activation of CD8+ cells by LCs denotes a central role of LCs in CD8+ immunity in skin, and suggests that regulation of LC CD70 expression is important in enhancing immunity against cutaneous epithelial pathogens and cancer.

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More information

e-pub ahead of print date: 1 March 2012
Published date: June 2012
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 340539
URI: http://eprints.soton.ac.uk/id/eprint/340539
ISSN: 0022-202X
PURE UUID: 935dc765-575e-4c7a-988e-7b8897d9aa12

Catalogue record

Date deposited: 25 Jun 2012 13:11
Last modified: 18 Jul 2017 05:43

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Contributors

Author: Marta E. Polak
Author: Louise Newell
Author: Vadim Y. Taraban
Author: Christopher Pickard
Author: Eugene Healy
Author: Peter S. Friedmann

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