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The paradox of matrix metalloproteinases in infectious disease

Elkington, P. T. G., O'Kane, C. M. and Friedland, J. S. (2005) The paradox of matrix metalloproteinases in infectious disease Clinical and Experimental Immunology, 142, (1), pp. 12-20. (doi:10.1111/j.1365-2249.2005.02840.x). (PMID:16178851).

Record type: Article


Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that perform multiple roles in the normal immune response to infection. MMPs facilitate leucocyte recruitment, cytokine and chemokine processing, defensin activation and matrix remodelling. However, excess MMP activity following infection may lead to immunopathology that causes host morbidity or mortality and favours pathogen dissemination or persistence. Here, we review the normal functions of MMPs in immunity and then discuss viral and bacterial infections where excess MMP activity has been implicated in pathology, specifically examining HIV, HTLV-1, hepatitis B, endotoxin shock, Helicobacter pylori and Mycobacterium tuberculosis. Tissue destruction may be exacerbated further by bacterial-derived enzymes which activate the host pro-MMPs. Finally, the potential for therapeutic targeting of excess MMP activity in infection is considered.

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Published date: October 2005
Keywords: HIV, immunopathology, infection, matrix metalloproteinase, tuberculosis
Organisations: Faculty of Medicine


Local EPrints ID: 340670
ISSN: 0009-9104
PURE UUID: ba1c1936-76a0-4a5f-a150-d86ae26f733c
ORCID for P. T. G. Elkington: ORCID iD

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Date deposited: 29 Jun 2012 09:27
Last modified: 18 Jul 2017 05:42

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Author: C. M. O'Kane
Author: J. S. Friedland

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