Network-based approaches for extending the Wnt signaling pathway and identifying context-specific sub-networks
Network-based approaches for extending the Wnt signaling pathway and identifying context-specific sub-networks
Wnt signaling is a critically important signaling pathway regulating embryogenesis and differentiation, and is broadly conserved amongst multicellular animals. In addition, dys-regulation of Wnt signaling contributes to the pathogenesis of many human cancers, in particular colorectal cancer. Core members of the Wnt signaling pathway are quite well defined, although it has become apparent that a much broader network of interacting proteins regulates Wnt signaling activity. The goal of this paper is first to identify novel members of the Wnt regulatory network and second, to identify subnetworks of the larger Wnt signaling network that are active in different biological contexts. We address these two questions using complementary computational approaches and show how these approaches may identify potentially novel Wnt signaling proteins as well as defining Wnt sub-networks active in different stages of colorectal cancer.
Wnt signaling network, eigenvector centrality, random walk, sub-network, simulated annealing
Saha, Sudipto
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Roman, Theodore
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Galnte, Alex
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Koyuturk, Mehmet
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Ewing, Rob M.
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Saha, Sudipto
77b0a09f-c013-4418-b3b5-659cca46fe9d
Roman, Theodore
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Galnte, Alex
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Koyuturk, Mehmet
4320991e-860d-4599-b32e-e438e4d8bad5
Ewing, Rob M.
022c5b04-da20-4e55-8088-44d0dc9935ae
Saha, Sudipto, Roman, Theodore, Galnte, Alex, Koyuturk, Mehmet and Ewing, Rob M.
(2012)
Network-based approaches for extending the Wnt signaling pathway and identifying context-specific sub-networks.
[in special issue: Integrative data analysis in systems biology]
International Journal of Computational Biology and Drug Design.
(In Press)
Abstract
Wnt signaling is a critically important signaling pathway regulating embryogenesis and differentiation, and is broadly conserved amongst multicellular animals. In addition, dys-regulation of Wnt signaling contributes to the pathogenesis of many human cancers, in particular colorectal cancer. Core members of the Wnt signaling pathway are quite well defined, although it has become apparent that a much broader network of interacting proteins regulates Wnt signaling activity. The goal of this paper is first to identify novel members of the Wnt regulatory network and second, to identify subnetworks of the larger Wnt signaling network that are active in different biological contexts. We address these two questions using complementary computational approaches and show how these approaches may identify potentially novel Wnt signaling proteins as well as defining Wnt sub-networks active in different stages of colorectal cancer.
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Accepted/In Press date: June 2012
Keywords:
Wnt signaling network, eigenvector centrality, random walk, sub-network, simulated annealing
Organisations:
Faculty of Natural and Environmental Sciences, Centre for Biological Sciences
Identifiers
Local EPrints ID: 340678
URI: http://eprints.soton.ac.uk/id/eprint/340678
ISSN: 1756-0756
PURE UUID: 0204b923-6aec-4261-a3e5-e4c58ff1faf9
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Date deposited: 29 Jun 2012 08:57
Last modified: 15 Mar 2024 03:44
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Contributors
Author:
Sudipto Saha
Author:
Theodore Roman
Author:
Alex Galnte
Author:
Mehmet Koyuturk
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