The University of Southampton
University of Southampton Institutional Repository

MMP12, lung function, and COPD in high-risk populations

Elkington, Paul T. and Cooke, Graham S. (2010) MMP12, lung function, and COPD in high-risk populations New England Journal of Medicine, 362, (13), pp. 1241-1242. (PMID:20018959).

Record type: Article


Hunninghake et al. (Dec. 31 issue)1 report an association between single-nucleotide polymorphisms (SNPs) in MMP12 and lung function in children with asthma and in adults who smoke, as well as an association with a reduced risk of chronic obstructive pulmonary disease (COPD) in adult smokers. However, a statistical genetic association may be observed when the implicated SNP is in strong linkage disequilibrium with another ungenotyped, but “causative,” SNP, often one that is in close proximity to the implicated SNP. To determine whether their findings could be explained by linkage disequilibrium, the authors present data for neighboring genes MMP3 and MMP13. Surprisingly, the authors did not present data for MMP1 (encoding interstitial collagenase), which is adjacent to MMP3 on chromosome 11 and is closer to MMP12 than is MMP13. Moreover, MMP1 has been strongly implicated in the pathogenesis of both COPD2 and asthma.3 It is a testable hypothesis that MMP1 encodes the protease that drives lung pathology. The association described by Hunninghake et al. could be attributable to SNPs within MMP1.

Full text not available from this repository.

More information

Published date: 1 April 2010
Organisations: Faculty of Medicine


Local EPrints ID: 340691
PURE UUID: 805c6cd4-e5d4-4b99-9524-a3bdf0aa6390
ORCID for Paul T. Elkington: ORCID iD

Catalogue record

Date deposited: 28 Jun 2012 16:15
Last modified: 18 Jul 2017 05:42

Export record


Author: Graham S. Cooke

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.